The Anti-PAF1 Antibody (CAB3437) is a high-quality polyclonal antibody specifically designed for research involving the PAF1 protein. PAF1 is a critical component of the RNA polymerase II complex and plays a crucial role in regulating gene expression and chromatin modifications.This antibody, produced through immunization of rabbits, is highly reactive with human samples and is validated for use in Western blot applications. It binds specifically to the PAF1 protein, allowing for accurate detection and analysis in various cell types. This makes it an ideal tool for researchers studying transcriptional regulation, epigenetics, and gene expression.
PAF1 is known to be involved in various cellular processes, including transcription elongation, mRNA processing, and DNA repair. Dysregulation of PAF1 has been linked to diseases such as cancer, developmental disorders, and neurological conditions. Understanding the role of PAF1 in these contexts is essential for the development of targeted therapies and diagnostic tools.Overall, the Anti-PAF1 Antibody (CAB3437) is a valuable tool for researchers interested in unraveling the complexities of gene expression and chromatin dynamics, ultimately contributing to advancements in the fields of molecular biology, genetics, and personalized medicine.
Product Name:
PAF1 Rabbit Monoclonal Antibody
SKU:
CAB3437
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PAF1 (NP_061961.2).
This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
54623
Clone Number:
ARC2019
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using PAF1 Rabbit mAb (CAB3437) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
