The Anti-LEO1 Antibody (CAB8806) is a valuable tool for researchers studying LEO1, a key component of the RNA polymerase-associated factor 1 complex involved in transcription elongation. This polyclonal antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot and immunohistochemistry applications.LEO1 is essential for proper transcriptional regulation and plays a crucial role in gene expression. Its dysregulation has been linked to various diseases, including cancer and developmental disorders. By targeting LEO1 with this antibody, researchers can investigate its role in transcriptional processes, potentially leading to a better understanding of disease mechanisms and the development of targeted therapies.
The Anti-LEO1 Antibody (CAB8806) offers a reliable method for detecting and analyzing LEO1 protein levels in different cell types, making it an ideal choice for studies in molecular biology, oncology, and developmental biology. By elucidating the functions of LEO1, researchers can gain insights into its involvement in disease pathology and potentially identify new therapeutic targets.
Product Name:
LEO1 Rabbit Polyclonal Antibody
SKU:
CAB8806
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 340-570 of human LEO1 (NP_620147.1).
LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).
Purification Method:
Affinity purification
Gene ID:
123169
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using LEO1 Rabbit pAb (CAB8806) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
