The KRT80 Monoclonal Antibody (CAB5165) is specifically designed for research involving KRT80, a member of the keratin protein family that plays a crucial role in maintaining the structural integrity of epithelial cells. This antibody, produced through a monoclonal process, exhibits high specificity and sensitivity towards human samples, making it a reliable tool for various immunohistochemistry and immunofluorescence applications.KRT80, a type II cytokeratin, is predominantly expressed in epithelial tissues and has been implicated in cell migration, adhesion, and differentiation processes.
Its dysregulation has been associated with various pathological conditions, including cancer progression and metastasis. By targeting KRT80, researchers can explore its functional roles in cell biology and disease development, providing valuable insights for potential diagnostic and therapeutic strategies in cancer research and regenerative medicine.
Product Name:
KRT80 Polyclonal Antibody
SKU:
CAB5165
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 242-452 of human KRT80 (NP_872313.2).
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene's expression profile shows that it encodes a type II epithelial keratin, although structurally the encoded protein is more like a type II hair keratin. This protein is involved in cell differentiation, localizing near desmosomal plaques in earlier stages of differentiation but then dispersing throughout the cytoplasm in terminally differentiating cells. The type II keratins are clustered in a region of chromosome 12q13. Two transcript variants encoding two different fully functional isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
144501
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunofluorescence analysis of rat skin using KRT80 Rabbit pAb (CAB5165) at dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining.
