Anti-IL12A Antibody (CAB20383)

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SKU:
CAB20383
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
P35
CLMF
NFSK
NKSF1
IL-12A
Frequently bought together:

Description

Product Name:IL12A Rabbit pAb
Product Code:CAB20383
Size:50uL, 100uL
Synonyms:P35, CLMF, NFSK, NKSF1, IL-12A
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human IL12A.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:RAW264.7, Recombinant Human IL12A/NKSF1 Protein
Immunogen:Recombinant protein of human IL12A.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3592
Uniprot:P29459
Calculated MW:24kDa
Observed MW:35KDa/75KDa
UniProt Protein Function:IL12A: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-6 superfamily.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted; Cytokine

Chromosomal Location of Human Ortholog: 3q25.33

Cellular Component: extracellular region; extracellular space; interleukin-12 complex

Molecular Function:cytokine activity; growth factor activity; interleukin-12 beta subunit binding; interleukin-12 receptor binding; interleukin-27 binding; protein binding; protein heterodimerization activity

Biological Process: cell cycle arrest; cell migration; defense response to Gram-positive bacterium; immune response; negative regulation of interleukin-17 production; negative regulation of smooth muscle cell proliferation; positive regulation of cell adhesion; positive regulation of interferon-gamma production; positive regulation of lymphocyte proliferation; positive regulation of mononuclear cell proliferation; positive regulation of natural killer cell activation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of NK T cell activation; positive regulation of T cell mediated cytotoxicity; positive regulation of T cell proliferation; positive regulation of tyrosine phosphorylation of Stat4 protein; response to lipopolysaccharide; response to UV-B; response to virus

NCBI Summary:This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]
UniProt Code:P29459
NCBI GenInfo Identifier:20141534
NCBI Gene ID:3592
NCBI Accession:P29459.2
UniProt Secondary Accession:P29459,Q96QZ1,
UniProt Related Accession:P29459
Molecular Weight:24,874 Da
NCBI Full Name:Interleukin-12 subunit alpha
NCBI Synonym Full Names:interleukin 12A
NCBI Official Symbol:IL12A  
NCBI Official Synonym Symbols:P35; CLMF; NFSK; NKSF1; IL-12A  
NCBI Protein Information:interleukin-12 subunit alpha
UniProt Protein Name:Interleukin-12 subunit alpha
UniProt Synonym Protein Names:Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; NK cell stimulatory factor chain 1; NKSF1
Protein Family:Interleukin
UniProt Gene Name:IL12A  
UniProt Entry Name:IL12A_HUMAN

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