Anti-Human TCR Vα24-Jα18 (iNKT cell) - Purified Invivo Antibody (IVMB0278)

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SKU:
IVMB0278
Product Type:
In Vivo Monoclonal Antibody
Clone:
6B11
Protein:
TCR V&alpha
Isotype:
IgG1 k
Reactivity:
Human
Synonyms:
TCR V alpha24-J alpha18
TCR V alpha24-J alphaQ
invariant NKT cell
iNKT
Research Area:
Immunology
Host Species:
Mouse
Applications:
FC

Description

Product Name:Anti-Human TCR Vα24-Jα18 (iNKT cell) - Purified Invivo Antibody
Product Code:IVMB0278
Clone:6B11
Protein:TCR Vα24-Jα18
Product Type:Monoclonal Antibody
Synonyms:TCR Vα24-Jα18, TCR Vα24-JαQ, invariant NKT cell, iNKT
Isotype:IgG1 k
Reactivity:Human
Applications:FC
Formulation:This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Product Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Applications:FC
Reactivity:Human
Host Species:Mouse
Specificity:Clone 6B11 recognizes the invariant CDR3 region of the human Vα24-Jα18 TCR.
Antigen Distribution:The Vα24-Jα18 TCR is expressed on iNKT cells.
Concentration:0.5 mg/ml
Formulation:This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:This purified antibody is stable when stored at 2-8°C. Do not freeze.

TCR Vα24-Jα18 antibody, 6B11, recognizes the CDR3 region of the V alpha 24 and J alpha 18 TCR alpha locus (Vα24-Jα18). The Vα24-Jα18 semi-invariant TCR is expressed on a highly conserved T cell subset, named invariant natural killer T (iNKT cells), which also express NK cell-associated molecules. The Vα24-Jα18 TCR recognizes lipid antigens, such as α-galactosylceramide (α-GalCer), presented by the MHC class I-like molecule CD1d1. Following activation, iNKT cells rapidly proliferate and produce large amounts of IL-4, IFNgamma, and cytolytic mediators2,3. iNKT cells have both inflammatory and immunoregulatory functions and are implicated in anti-tumor immunity, protection against infections, suppression of autoimmunity, and the development of inflammatory diseases4.

Protein:TCR Vα24-Jα18
Ligand/Receptor:Glycolipid loaded CD1d
Research Area:Immunology
Shipping:2-8°C
NCBI Gene Bank ID:28659

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