The Anti-HTR4 Antibody (CAB2802) is a highly specific and sensitive tool for research involving the HTR4 protein, a receptor involved in serotonin signaling. This polyclonal antibody, produced in rabbits, shows strong reactivity with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.HTR4, also known as the 5-HT4 receptor, plays a crucial role in modulating neurotransmission and has been implicated in various physiological processes, including gastrointestinal motility and cognition.
Dysregulation of HTR4 signaling has been linked to neurological and psychiatric disorders, making it a promising target for drug development and therapeutic strategies.This antibody offers researchers the ability to study HTR4 expression and function in different cell types and tissues, providing valuable insights into its role in health and disease. By understanding the mechanisms of HTR4 signaling, scientists may uncover potential therapeutic interventions for conditions such as depression, anxiety, and gastrointestinal disorders.
Product Name:
HTR4 Rabbit Polyclonal Antibody
SKU:
CAB2802
Size:
20uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 350-384 of human HTR4 (NP_000861.1).
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described.
Purification Method:
Affinity purification
Gene ID:
3360
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HTR4 antibody (CAB2802) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
