Anti-EDG2/LPA-1 Antibody (CAB19671)
- SKU:
- CAB19671
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- EDG2
- GPR26
- Gpcr26
- LPA1
- Mrec1.3
- VZG1
- edg-2
- rec.1.3
- vzg-1
Description
| Product Name: | EDG2/LPA-1 Rabbit mAb |
| Product Code: | CAB19671 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | EDG2, GPR26, Gpcr26, LPA1, Mrec1.3, VZG1, edg-2, rec.1.3, vzg-1 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human EDG2/LPA-1 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Jurkat, Mouse lung, Mouse brain, Rat brain |
| Immunogen: | A synthesized peptide derived from human EDG2/LPA-1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1902 |
| Uniprot: | Q92633 |
| Calculated MW: | 39kDa |
| Observed MW: | 41KDa |
| UniProt Protein Function: | LPAR1: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 9q31.3 Cellular Component: cell soma; cell surface; cytosol; dendritic shaft; dendritic spine; endocytic vesicle; endosome; integral to plasma membrane; plasma membrane Molecular Function:G-protein alpha-subunit binding; G-protein coupled receptor activity; PDZ domain binding; protein binding Biological Process: activation of MAPK activity; bleb formation; cerebellum development; corpus callosum development; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; myelination; negative regulation of cAMP biosynthetic process; oligodendrocyte development; optic nerve development; phospholipase C activation; positive regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAPKKK cascade; positive regulation of Rho protein signal transduction; positive regulation of stress fiber formation; regulation of cell shape |
| NCBI Summary: | The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92633 |
| NCBI GenInfo Identifier: | 26454626 |
| NCBI Gene ID: | 1902 |
| NCBI Accession: | Q92633.3 |
| UniProt Secondary Accession: | Q92633,O00656, O00722, P78351, B4DK36, |
| UniProt Related Accession: | Q92633 |
| Molecular Weight: | 41,346 Da |
| NCBI Full Name: | Lysophosphatidic acid receptor 1 |
| NCBI Synonym Full Names: | lysophosphatidic acid receptor 1 |
| NCBI Official Symbol: | LPAR1 |
| NCBI Official Synonym Symbols: | EDG2; LPA1; VZG1; GPR26; edg-2; vzg-1; Gpcr26; Mrec1.3; rec.1.3 |
| NCBI Protein Information: | lysophosphatidic acid receptor 1 |
| UniProt Protein Name: | Lysophosphatidic acid receptor 1 |
| UniProt Synonym Protein Names: | Lysophosphatidic acid receptor Edg-2 |
| Protein Family: | Lysophosphatidic acid receptor |
| UniProt Gene Name: | LPAR1 |
| UniProt Entry Name: | LPAR1_HUMAN |
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