Anti-CPSF73 Antibody (CAB2222)
- SKU:
- CAB2222
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CPSF3
- CPSF-73
- CPSF73
- cleavage and polyadenylation specific factor 3
Frequently bought together:
Description
| Product Name: | CPSF73 Rabbit mAb |
| Product Code: | CAB2222 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CPSF3, CPSF-73, CPSF73, cleavage and polyadenylation specific factor 3 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CPSF73. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 293T, SH-SY5Y, Mouse liver, Mouse kidney, Mouse uterus, Rat spleen |
| Immunogen: | A synthesized peptide derived from human CPSF73. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 51692 |
| Uniprot: | Q9UKF6 |
| Cellular Location: | Nucleus |
| Calculated MW: | 77kDa |
| Observed MW: | 77KDa |
| UniProt Protein Function: | CPSF3: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP- dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF3 subfamily. |
| UniProt Protein Details: | Protein type:EC 3.1.27.-; RNA processing; RNA splicing; RNA-binding; Ribonuclease Chromosomal Location of Human Ortholog: 2p25.1 Cellular Component: mRNA cleavage and polyadenylation specificity factor complex; nucleoplasm Molecular Function:5'-3' exonuclease activity; endoribonuclease activity; protein binding; RNA binding Biological Process: histone mRNA 3'-end processing; mRNA 3'-end processing; mRNA cleavage; mRNA export from nucleus; mRNA polyadenylation; nuclear mRNA splicing, via spliceosome; termination of RNA polymerase II transcription |
| NCBI Summary: | This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing. [provided by RefSeq, Oct 2012] |
| UniProt Code: | Q9UKF6 |
| NCBI GenInfo Identifier: | 18203503 |
| NCBI Gene ID: | 51692 |
| NCBI Accession: | Q9UKF6.1 |
| UniProt Secondary Accession: | Q9UKF6,O14769, Q53RS2, Q96F36, |
| UniProt Related Accession: | Q9UKF6 |
| Molecular Weight: | 77kDa |
| NCBI Full Name: | Cleavage and polyadenylation specificity factor subunit 3 |
| NCBI Synonym Full Names: | cleavage and polyadenylation specific factor 3 |
| NCBI Official Symbol: | CPSF3 |
| NCBI Official Synonym Symbols: | CPSF73; CPSF-73 |
| NCBI Protein Information: | cleavage and polyadenylation specificity factor subunit 3 |
| UniProt Protein Name: | Cleavage and polyadenylation specificity factor subunit 3 |
| UniProt Synonym Protein Names: | Cleavage and polyadenylation specificity factor 73 kDa subunit; CPSF 73 kDa subunit; mRNA 3'-end-processing endonuclease CPSF-73 |
| Protein Family: | Cleavage and polyadenylation specificity factor |
| UniProt Gene Name: | CPSF3 |
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