Anti-CD84 Antibody (CAB2299)
- SKU:
- CAB2299
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CD84
- LY9B
- SLAMF5
- hCD84
- mCD84
- CD84 molecule
Frequently bought together:
Description
| Product Name: | CD84 Rabbit mAb |
| Product Code: | CAB2299 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CD84, LY9B, SLAMF5, hCD84, mCD84, CD84 molecule |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CD84. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat, K-562, Mouse spinal cord, Mouse spleen, Mouse thymus, Rat spinal cord |
| Immunogen: | A synthesized peptide derived from human CD84. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8832 |
| Uniprot: | Q9UIB8 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 60-85kDa |
| Observed MW: | 55-82KDa |
| UniProt Protein Function: | CD84: Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain- containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells. 7 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Immunoglobulin superfamily; Motility/polarity/chemotaxis; Cell surface Chromosomal Location of Human Ortholog: 1q24 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:protein binding Biological Process: adaptive immune response; blood coagulation; defense response; homophilic cell adhesion; innate immune response; leukocyte migration; negative regulation of granulocyte macrophage colony-stimulating factor production; negative regulation of interleukin-18 production; negative regulation of mast cell activation; negative regulation of mast cell degranulation |
| NCBI Summary: | This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q9UIB8 |
| NCBI GenInfo Identifier: | 74762772 |
| NCBI Gene ID: | 8832 |
| NCBI Accession: | Q9UIB8.1 |
| UniProt Secondary Accession: | Q9UIB8,O15430, O95266, O95660, Q5H9R1, Q6FHA8, Q8WLP1 Q8WWI8, Q9UF04, Q9UIB6, B2R8T1, B7Z3R8, |
| UniProt Related Accession: | Q9UIB8 |
| Molecular Weight: | 24,025 Da |
| NCBI Full Name: | SLAM family member 5 |
| NCBI Synonym Full Names: | CD84 molecule |
| NCBI Official Symbol: | CD84 |
| NCBI Official Synonym Symbols: | LY9B; hCD84; mCD84; SLAMF5 |
| NCBI Protein Information: | SLAM family member 5 |
| UniProt Protein Name: | SLAM family member 5 |
| UniProt Synonym Protein Names: | Cell surface antigen MAX.3; Hly9-beta; Leukocyte differentiation antigen CD84; Signaling lymphocytic activation molecule 5; CD_antigen: CD84 |
| Protein Family: | SLAM family |
| UniProt Gene Name: | CD84 |
| UniProt Entry Name: | SLAF5_HUMAN |
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