Anti-TYMS Antibody (RACO0380)
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주문- SKU:
- RACO0380
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- WB
- Application:
- ELISA
- Conjugation:
- Unconjugated
Description
Product Name: | TYMS Antibody |
Product SKU: | RACO0380 |
Size: | 50ul |
Host Species: | Homo sapiens (Human) |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:5000 |
Species Reactivity: | Human |
Immunogen: | A synthesized peptide derived from human Thymidylate Synthase |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Affinity-chromatography |
Clonality: | Monoclonal |
Isotype: | Rabbit IgG |
Conjugate: | Non-conjugated |
Background: | Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. |
Synonyms: | Thymidylate synthase (TS) (TSase) (EC 2.1.1.45), TYMS, TS |
Western Blot. Positive WB detected in Hela whole cell lysate 293T whole cell lysate 293 whole cell lysate Jurkat whole cell lysate HepG2 whole cell lysate HL-60 whole cell lysate All lanes Thymidylate Synthase antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1:50000 dilution. Predicted band size: 36, 32, 27 kDa. Observed band size: 36 kDa. |
UniProt Protein Function: | TYMS: an enzyme in the thymidylate synthase family. Polymorphisms serve as prognostic markers for determining modality of treatment in certain cancers. Genotyping helps predict toxicity to 5-FU-based chemotherapy in patients with colorectal cancer and the response to platinum-based chemotherapy in advanced NSCLC. A common polymorphism is a determinant of red blood cell folate and homocysteine concentrations. Homodimer. |
UniProt Protein Details: | Protein type:Nucleotide Metabolism - pyrimidine; Cofactor and Vitamin Metabolism - one carbon pool by folate; DNA repair, damage; EC 2.1.1.45; Mitochondrial; Methyltransferase Chromosomal Location of Human Ortholog: 18p11.32 Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix; cytoplasm; mitochondrial inner membrane; nucleolus; nucleus; cytosol Molecular Function:mRNA binding; protein homodimerization activity; nucleotide binding; drug binding; cofactor binding; thymidylate synthase activity; folic acid binding Biological Process: immortalization of host cell by virus; methylation; tetrahydrofolate metabolic process; circadian rhythm; uracil metabolic process; developmental growth; response to organophosphorus; response to toxin; response to glucocorticoid stimulus; dTTP biosynthetic process; response to vitamin A; pyrimidine base metabolic process; response to folic acid; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; aging; response to drug; organ regeneration; nucleobase, nucleoside and nucleotide metabolic process; dTMP biosynthetic process; deoxyribonucleoside monophosphate biosynthetic process; G1/S-specific transcription in mitotic cell cycle; response to ethanol; response to cytokine stimulus; cartilage development; pyrimidine nucleoside biosynthetic process; dUMP metabolic process; mitotic cell cycle; response to progesterone stimulus; G1/S transition of mitotic cell cycle |
NCBI Summary: | Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008] |
UniProt Code: | P04818 |
NCBI GenInfo Identifier: | 136611 |
NCBI Gene ID: | 7298 |
NCBI Accession: | P04818.3 |
UniProt Secondary Accession: | P04818,Q8WYK3, Q8WYK4, |
UniProt Related Accession: | P04818 |
Molecular Weight: | Calculated MW: 26kDa/31kDa/35kDaObserved MW: 36kDa |
NCBI Full Name: | Thymidylate synthase |
NCBI Synonym Full Names: | thymidylate synthetase |
NCBI Official Symbol: | TYMSÂ Â |
NCBI Official Synonym Symbols: | TS; TMS; HST422Â Â |
NCBI Protein Information: | thymidylate synthase; TSase |
UniProt Protein Name: | Thymidylate synthase |
Protein Family: | Thymidylate synthase |
UniProt Gene Name: | TYMSÂ Â |
UniProt Entry Name: | TYSY_HUMAN |