Anti-FCGR2A Antibody (RACO0468)
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주문- SKU:
- RACO0468
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- WB
- Application:
- ELISA
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Product Name: | FCGR2A Antibody |
Product SKU: | RACO0468 |
Size: | 50ul |
Host Species: | Homo sapiens (Human) |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:5000 |
Species Reactivity: | Human |
Immunogen: | A synthesized peptide derived from human CD32 |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Affinity-chromatography |
Clonality: | Monoclonal |
Isotype: | Rabbit IgG |
Conjugate: | Non-conjugated |
Background: | Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. |
Synonyms: | Low affinity immunoglobulin gamma Fc region receptor II-a (IgG Fc receptor II-a) (CDw32) (Fc-gamma RII-a) (Fc-gamma-RIIa) (FcRII-a) (CD antigen CD32), FCGR2A, CD32 FCG2 FCGR2A1 IGFR2 |
Western Blot. Positive WB detected in THP-1 whole cell lysate All lanes CD32 antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1:50000 dilution. Predicted band size: 35, 36 kDa. Observed band size: 45 kDa. |
UniProt Protein Function: | FCGR2A: low affinity receptor for the Fc region of IgGs. Binding to IgG initiates cellular responses against pathogens and soluble antigens. A type I membrane protein found on monocytes, neutrophils and platelets. SHP-1 associates with this protein to modulate signaling events in myeloid cells. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc.; Cell surface Chromosomal Location of Human Ortholog: 1q23 Cellular Component: plasma membrane Molecular Function:protein binding Disease: Malaria, Susceptibility To; Systemic Lupus Erythematosus |
NCBI Summary: | This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008] |
UniProt Code: | P12318 |
NCBI GenInfo Identifier: | 160332371 |
NCBI Gene ID: | 2212 |
NCBI Accession: | P12318.4 |
UniProt Secondary Accession: | P12318,Q8WUN1, Q8WW64, |
UniProt Related Accession: | P12318 |
Molecular Weight: | 34,930 Da |
NCBI Full Name: | Low affinity immunoglobulin gamma Fc region receptor II-a |
NCBI Synonym Full Names: | Fc fragment of IgG receptor IIa |
NCBI Official Symbol: | FCGR2AÂ Â |
NCBI Official Synonym Symbols: | CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1Â Â |
NCBI Protein Information: | low affinity immunoglobulin gamma Fc region receptor II-a |
UniProt Protein Name: | Low affinity immunoglobulin gamma Fc region receptor II-a |
UniProt Synonym Protein Names: | CDw32; Fc-gamma RII-a; Fc-gamma-RIIa; FcRII-a; CD_antigen: CD32 |
Protein Family: | Low affinity immunoglobulin gamma Fc region receptor |
UniProt Gene Name: | FCGR2AÂ Â |
UniProt Entry Name: | FCG2A_HUMAN |