UniProt Protein Function: | FCGR2A: low affinity receptor for the Fc region of IgGs. Binding to IgG initiates cellular responses against pathogens and soluble antigens. A type I membrane protein found on monocytes, neutrophils and platelets. SHP-1 associates with this protein to modulate signaling events in myeloid cells. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc.; Cell surface Chromosomal Location of Human Ortholog: 1q23 Cellular Component: plasma membrane Molecular Function:protein binding Disease: Malaria, Susceptibility To; Systemic Lupus Erythematosus |
NCBI Summary: | This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008] |
UniProt Code: | P12318 |
NCBI GenInfo Identifier: | 160332371 |
NCBI Gene ID: | 2212 |
NCBI Accession: | P12318.4 |
UniProt Secondary Accession: | P12318,Q8WUN1, Q8WW64, |
UniProt Related Accession: | P12318 |
Molecular Weight: | 34,930 Da |
NCBI Full Name: | Low affinity immunoglobulin gamma Fc region receptor II-a |
NCBI Synonym Full Names: | Fc fragment of IgG receptor IIa |
NCBI Official Symbol: | FCGR2A |
NCBI Official Synonym Symbols: | CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1 |
NCBI Protein Information: | low affinity immunoglobulin gamma Fc region receptor II-a |
UniProt Protein Name: | Low affinity immunoglobulin gamma Fc region receptor II-a |
UniProt Synonym Protein Names: | CDw32; Fc-gamma RII-a; Fc-gamma-RIIa; FcRII-a; CD_antigen: CD32 |
Protein Family: | Low affinity immunoglobulin gamma Fc region receptor |
UniProt Gene Name: | FCGR2A |
UniProt Entry Name: | FCG2A_HUMAN |