XRCC2 Antibody (PACO23156)
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주문- SKU:
- PACO23156
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | XRCC2 Antibody (PACO23156) |
Antibody SKU: | PACO23156 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from internal of human XRCC2. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from 293cells, using XRCC2 antibody. | |
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using XRCC2 antibody. |
Background: | Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. |
Synonyms: | X-RAY REPAIR; COMPLEMENTING DEFECTIVE; IN CHINESE HAMSTER; 2; |
UniProt Protein Function: | XRCC2: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Belongs to the RecA family. RAD51 subfamily. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 7q36.1 Cellular Component: centrosome; nucleoplasm; replication fork Molecular Function:DNA-dependent ATPase activity; double-stranded DNA binding; endodeoxyribonuclease activity; four-way junction DNA binding; protein binding; recombinase activity; single-stranded DNA binding Biological Process: centrosome organization and biogenesis; DNA repair; DNA synthesis during DNA repair; double-strand break repair via homologous recombination; meiosis; meiotic DNA recombinase assembly; meiotic recombination; mitotic cell cycle; mitotic recombination; response to ionizing radiation; strand displacement; strand invasion |
NCBI Summary: | This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008] |
UniProt Code: | O43543 |
NCBI GenInfo Identifier: | 20140429 |
NCBI Gene ID: | 7516 |
NCBI Accession: | O43543.1 |
UniProt Secondary Accession: | O43543,B2R925, |
UniProt Related Accession: | O43543 |
Molecular Weight: | 31,956 Da |
NCBI Full Name: | DNA repair protein XRCC2 |
NCBI Synonym Full Names: | X-ray repair cross complementing 2 |
NCBI Official Symbol: | XRCC2 |
NCBI Official Synonym Symbols: | FANCU |
NCBI Protein Information: | DNA repair protein XRCC2 |
UniProt Protein Name: | DNA repair protein XRCC2 |
UniProt Synonym Protein Names: | X-ray repair cross-complementing protein 2 |
Protein Family: | DNA repair protein |
UniProt Gene Name: | XRCC2 |
UniProt Entry Name: | XRCC2_HUMAN |