TP53INP1 Antibody (PACO20163)
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주문- SKU:
- PACO20163
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TP53INP1 Antibody (PACO20163) |
Antibody SKU: | PACO20163 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human TP53INP1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20163(TP53INP1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 40 µg, Lane 1-3: Human fetal liver tissue, 293T cells, 231 cells, Primary antibody: PACO20163(TP53INP1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. | |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20163(TP53INP1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | TP53INP1 (tumor protein p53-inducible nuclear protein 1), also known as p53DINP1, SIP or Teap, is a 240 amino acid, protein that localizes to nuclear bodies and exists as two alternatively spliced isoforms, designated p53DINP1a and p53DINP1b. Expressed ubiquitously with higher expression in testis, pancreas and spleen tissue, TP53INP1 functions in response to double-stranded DNA breaks and regulates p53-mediated apoptosis, specifically by phosphorylating human p53 at Ser 46, an event that leads to cell death. Additionally, TP53INP1 is thought to interact with p73 and may be involved in the regulation of p73-controlled cell cycle progression. TP53INP1 expression is downregulated in pancreatic ductal adenocarcinomas, suggesting that, via its ability to induce cell death, TP53INP1 plays a role in tumor suppression. |
Synonyms: | tumor protein p53 inducible nuclear protein 1 |
UniProt Protein Function: | TP53INP1: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Apoptosis; Tumor suppressor; Cell cycle regulation Chromosomal Location of Human Ortholog: 8q22 Cellular Component: PML body; autophagic vacuole; cytoplasmic vesicle; nucleus; cytosol Molecular Function:antioxidant activity; protein binding Biological Process: negative regulation of cell proliferation; transcription, DNA-dependent; response to heat; apoptosis; positive regulation of transcription, DNA-dependent; autophagic cell death; response to stress; cell cycle arrest; negative regulation of cell migration; positive regulation of autophagy; autophagic vacuole formation |
UniProt Code: | Q96A56 |
NCBI GenInfo Identifier: | 209180469 |
NCBI Gene ID: | 94241 |
NCBI Accession: | NP_001129205.1 |
UniProt Secondary Accession: | Q96A56,Q969R9, B2RCE5, |
UniProt Related Accession: | Q96A56 |
Molecular Weight: | 27,366 Da |
NCBI Full Name: | tumor protein p53-inducible nuclear protein 1 isoform b |
NCBI Synonym Full Names: | tumor protein p53 inducible nuclear protein 1 |
NCBI Official Symbol: | TP53INP1 |
NCBI Official Synonym Symbols: | SIP; Teap; p53DINP1; TP53DINP1; TP53INP1A; TP53INP1B |
NCBI Protein Information: | tumor protein p53-inducible nuclear protein 1; p53-inducible p53DINP1; stress-induced protein; p53-dependent damage-inducible nuclear protein 1 |
UniProt Protein Name: | Tumor protein p53-inducible nuclear protein 1 |
UniProt Synonym Protein Names: | Stress-induced protein; p53-dependent damage-inducible nuclear protein 1 |
Protein Family: | Tumor protein p53-inducible nuclear protein |
UniProt Gene Name: | TP53INP1 |
UniProt Entry Name: | T53I1_HUMAN |