TP53INP1 Antibody (PACO01646)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO01646
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TP53INP1 Antibody |
Antibody SKU: | PACO01646 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
Species Reactivity: | Human |
Immunogen: | synthesized peptide derived from the C-terminal region of human TP53INP1. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | TP53INP1; P53DINP1; SIP; Tumor protein p53-inducible nuclear protein 1; Stress-induced protein; p53-dependent damage-inducible nuclear protein 1; p53DINP1 |
UniProt Protein Function: | TP53INP1: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Apoptosis; Tumor suppressor; Cell cycle regulation Chromosomal Location of Human Ortholog: 8q22 Cellular Component: PML body; autophagic vacuole; cytoplasmic vesicle; nucleus; cytosol Molecular Function:antioxidant activity; protein binding Biological Process: negative regulation of cell proliferation; transcription, DNA-dependent; response to heat; apoptosis; positive regulation of transcription, DNA-dependent; autophagic cell death; response to stress; cell cycle arrest; negative regulation of cell migration; positive regulation of autophagy; autophagic vacuole formation |
UniProt Code: | Q96A56 |
NCBI GenInfo Identifier: | 209180469 |
NCBI Gene ID: | 94241 |
NCBI Accession: | NP_001129205.1 |
UniProt Secondary Accession: | Q96A56,Q969R9, B2RCE5, |
UniProt Related Accession: | Q96A56 |
Molecular Weight: | 27,366 Da |
NCBI Full Name: | tumor protein p53-inducible nuclear protein 1 isoform b |
NCBI Synonym Full Names: | tumor protein p53 inducible nuclear protein 1 |
NCBI Official Symbol: | TP53INP1 |
NCBI Official Synonym Symbols: | SIP; Teap; p53DINP1; TP53DINP1; TP53INP1A; TP53INP1B |
NCBI Protein Information: | tumor protein p53-inducible nuclear protein 1; p53-inducible p53DINP1; stress-induced protein; p53-dependent damage-inducible nuclear protein 1 |
UniProt Protein Name: | Tumor protein p53-inducible nuclear protein 1 |
UniProt Synonym Protein Names: | Stress-induced protein; p53-dependent damage-inducible nuclear protein 1 |
Protein Family: | Tumor protein p53-inducible nuclear protein |
UniProt Gene Name: | TP53INP1 |
UniProt Entry Name: | T53I1_HUMAN |