STAT4 Antibody (PACO51982)
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주문- SKU:
- PACO51982
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | STAT4 Antibody (PACO51982) |
Antibody SKU: | PACO51982 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Recombinant Human Signal transducer and activator of transcription 4 protein (569-748AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: HepG2 whole cell lysate, Hela whole cell lysate, PC-3 whole cell lysate, K562 whole cell lyaste, Mouse brain tissue, Rat liver tissue. All lanes: STAT4 antibody at 1µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 86 kDa. Observed band size: 86 kDa. | |
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO51982 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human liver cancer using PACO51982 at dilution of 1:100. |
Background: | Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling. |
Synonyms: | Signal transducer and activator of transcription 4, STAT4 |
UniProt Protein Function: | STAT4: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. |
UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 2q32.2-q32.3 Cellular Component: nucleoplasm; cytoplasm Molecular Function:protein binding; signal transducer activity; sequence-specific DNA binding; transcription factor activity Biological Process: cell proliferation; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; JAK-STAT cascade; protein amino acid phosphorylation Disease: Systemic Lupus Erythematosus, Susceptibility To, 11 |
NCBI Summary: | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] |
UniProt Code: | Q14765 |
NCBI GenInfo Identifier: | 6226158 |
NCBI Gene ID: | 6775 |
NCBI Accession: | Q14765.1 |
UniProt Secondary Accession: | Q14765,Q96NZ6, |
UniProt Related Accession: | Q14765 |
Molecular Weight: | 85,941 Da |
NCBI Full Name: | Signal transducer and activator of transcription 4 |
NCBI Synonym Full Names: | signal transducer and activator of transcription 4 |
NCBI Official Symbol: | STAT4 |
NCBI Official Synonym Symbols: | SLEB11 |
NCBI Protein Information: | signal transducer and activator of transcription 4 |
UniProt Protein Name: | Signal transducer and activator of transcription 4 |
Protein Family: | Protein slender lobes |
UniProt Gene Name: | STAT4 |
UniProt Entry Name: | STAT4_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |