STAT4 Antibody (PACO13876)
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주문- SKU:
- PACO13876
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | STAT4 Antibody (PACO13876) |
Antibody SKU: | PACO13876 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:3000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human STAT4 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO13876(STAT4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO13876(STAT4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. |
Synonyms: | Signal transducer and activator of transcription 4 |
UniProt Protein Function: | STAT4: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. |
UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 2q32.2-q32.3 Cellular Component: nucleoplasm; cytoplasm Molecular Function:protein binding; signal transducer activity; sequence-specific DNA binding; transcription factor activity Biological Process: cell proliferation; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; JAK-STAT cascade; protein amino acid phosphorylation Disease: Systemic Lupus Erythematosus, Susceptibility To, 11 |
NCBI Summary: | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] |
UniProt Code: | Q14765 |
NCBI GenInfo Identifier: | 6226158 |
NCBI Gene ID: | 6775 |
NCBI Accession: | Q14765.1 |
UniProt Secondary Accession: | Q14765,Q96NZ6, |
UniProt Related Accession: | Q14765 |
Molecular Weight: | 85,941 Da |
NCBI Full Name: | Signal transducer and activator of transcription 4 |
NCBI Synonym Full Names: | signal transducer and activator of transcription 4 |
NCBI Official Symbol: | STAT4 |
NCBI Official Synonym Symbols: | SLEB11 |
NCBI Protein Information: | signal transducer and activator of transcription 4 |
UniProt Protein Name: | Signal transducer and activator of transcription 4 |
Protein Family: | Protein slender lobes |
UniProt Gene Name: | STAT4 |
UniProt Entry Name: | STAT4_HUMAN |
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