SLC22A5 Antibody (PACO05089)
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주문- SKU:
- PACO05089
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | SLC22A5 Antibody (PACO05089) |
Antibody SKU: | PACO05089 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from the Internal region of human OCTN2. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | SLC22A5; OCTN2; Solute carrier family 22 member 5; High-affinity sodium-dependent carnitine cotransporter; Organic cation/carnitine transporter 2 |
UniProt Protein Function: | SLC22A5: Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3. Defects in SLC22A5 are the cause of systemic primary carnitine deficiency (CDSP). CDSP is an autosomal recessive disorder of fatty acid oxidation caused by defective carnitine transport. Present early in life with hypoketotic hypoglycemia and acute metabolic decompensation, or later in life with skeletal myopathy or cardiomyopathy. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter Chromosomal Location of Human Ortholog: 5q23.3 Cellular Component: brush border membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane; integral to membrane Molecular Function:protein binding; antibiotic transporter activity; symporter activity; carnitine transporter activity; drug transporter activity; quaternary ammonium group transmembrane transporter activity; ATP binding; PDZ domain binding Biological Process: quaternary ammonium group transport; drug transport; antibiotic transport; sodium ion transport; multidrug transport; transmembrane transport; carnitine transport; quorum sensing during interaction with host Disease: Carnitine Deficiency, Systemic Primary |
NCBI Summary: | Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy. [provided by RefSeq, Jul 2008] |
UniProt Code: | O76082 |
NCBI GenInfo Identifier: | 8928257 |
NCBI Gene ID: | 6584 |
NCBI Accession: | O76082.1 |
UniProt Secondary Accession: | O76082,Q6ZQZ8, Q96EH6, A2Q0V1, B2R844, D3DQ87, |
UniProt Related Accession: | O76082 |
Molecular Weight: | 557 |
NCBI Full Name: | Solute carrier family 22 member 5 |
NCBI Synonym Full Names: | solute carrier family 22 (organic cation/carnitine transporter), member 5 |
NCBI Official Symbol: | SLC22A5 |
NCBI Official Synonym Symbols: | CDSP; OCTN2; OCTN2VT |
NCBI Protein Information: | solute carrier family 22 member 5; organic cation/carnitine transporter 2; high-affinity sodium dependent carnitine cotransporter |
UniProt Protein Name: | Solute carrier family 22 member 5 |
UniProt Synonym Protein Names: | High-affinity sodium-dependent carnitine cotransporter; Organic cation/carnitine transporter 2 |
Protein Family: | Solute carrier family |
UniProt Gene Name: | SLC22A5 |
UniProt Entry Name: | S22A5_HUMAN |