SETD7 Antibody (PACO16466)
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주문- SKU:
- PACO16466
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SETD7 Antibody (PACO16466) |
Antibody SKU: | PACO16466 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human SETD7 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16466(SETD7 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The methylation of histones plays a pivotal role in the regulation of chromatin structure and gene expression. Histone methylation can occur on Arg or Lys residues, with an exquisite site selectivity for Lys methylation at specific positions in the N-termini of histones H3 and H4. SET7/9, a histone methyltransferase (HMTase), which transfers methyl groups to Lys4 of histone H3, forms a complex with S-adenosyl-L-methionine. This complex contains an active site consisting of a binding pocket where an AdoMet molecule in an unusual conformation binds, a narrow substrate-specific channel that only unmethylated lysine residues can access and a catalytic tyrosine residue. |
Synonyms: | SET domain containing (lysine methyltransferase) 7 |
UniProt Protein Function: | Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. |
UniProt Code: | Q8WTS6 |
NCBI GenInfo Identifier: | 25091217 |
NCBI Gene ID: | 80854 |
NCBI Accession: | Q8WTS6.1 |
UniProt Secondary Accession: | Q8WTS6,Q0VAH3, Q4W5A9, Q9C0E6, B5WWL3, |
UniProt Related Accession: | Q8WTS6 |
Molecular Weight: | 40,721 Da |
NCBI Full Name: | Histone-lysine N-methyltransferase SETD7 |
NCBI Synonym Full Names: | SET domain containing lysine methyltransferase 7 |
NCBI Official Symbol: | SETD7 |
NCBI Official Synonym Symbols: | KMT7; SET7; SET9; SET7/9 |
NCBI Protein Information: | histone-lysine N-methyltransferase SETD7 |
UniProt Protein Name: | Histone-lysine N-methyltransferase SETD7 |
UniProt Synonym Protein Names: | Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7; Lysine N-methyltransferase 7; SET domain-containing protein 7; SET7/9 |
Protein Family: | Histone-lysine N-methyltransferase |
UniProt Gene Name: | SETD7 |
UniProt Entry Name: | SETD7_HUMAN |