RPS6KA6 Antibody (PACO18625)
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주문- SKU:
- PACO18625
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RPS6KA6 Antibody (PACO18625) |
Antibody SKU: | PACO18625 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human RPS6KA6 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18625(RPS6KA6 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO18625(RPS6KA6 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. |
Synonyms: | ribosomal protein S6 kinase, 90kDa, polypeptide 6 |
UniProt Protein Function: | RSK4: an AGC kinase of the RSK family. Phosphorylates a wide range of substrates including ribosomal protein S6. Implicated in the activation of the mitogen- activated kinase cascade. May play a role in normal neuronal development. |
UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; AGC group; RSK family; RSK subfamily Chromosomal Location of Human Ortholog: Xq21 Cellular Component: cytoplasm; cytosol; mitochondrion; nucleolus; nucleoplasm; nucleus Molecular Function:kinase activity; protein kinase activity; protein serine/threonine kinase activity Biological Process: central nervous system development; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; negative regulation of embryonic development; signal transduction |
NCBI Summary: | This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010] |
UniProt Code: | Q9UK32 |
NCBI GenInfo Identifier: | 11133131 |
NCBI Gene ID: | 27330 |
NCBI Accession: | Q9UK32.1 |
UniProt Secondary Accession: | Q9UK32,Q6FHX2, Q8WX28, Q9H4S6, B2R854, B7ZL90, |
UniProt Related Accession: | Q9UK32 |
Molecular Weight: | 84,093 Da |
NCBI Full Name: | Ribosomal protein S6 kinase alpha-6 |
NCBI Synonym Full Names: | ribosomal protein S6 kinase A6 |
NCBI Official Symbol: | RPS6KA6 |
NCBI Official Synonym Symbols: | RSK4; PP90RSK4 |
NCBI Protein Information: | ribosomal protein S6 kinase alpha-6 |
UniProt Protein Name: | Ribosomal protein S6 kinase alpha-6 |
UniProt Synonym Protein Names: | 90 kDa ribosomal protein S6 kinase 6; p90-RSK 6; p90RSK6; Ribosomal S6 kinase 4; RSK-4; pp90RSK4 |
Protein Family: | Ribosomal protein S6 kinase |
UniProt Gene Name: | RPS6KA6 |
UniProt Entry Name: | KS6A6_HUMAN |