RPS6KA6 Antibody (PACO23292)
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주문- SKU:
- PACO23292
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RPS6KA6 Antibody (PACO23292) |
Antibody SKU: | PACO23292 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from internal of human S6K- alpha 6. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from K562 cells and HT-29 cells, using S6K-alpha 6 antibody. | |
Immunohistochemistry analysis of paraffin-embedded human brain tissue using S6K- alpha 6 antibody. |
Background: | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. |
Synonyms: | 90 kDa ribosomal protein S6 kinase 6; EC 2.7.1.37; EC 2.7.11.1; KS6A6; RPS6KA6 |
UniProt Protein Function: | RSK4: an AGC kinase of the RSK family. Phosphorylates a wide range of substrates including ribosomal protein S6. Implicated in the activation of the mitogen- activated kinase cascade. May play a role in normal neuronal development. |
UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; AGC group; RSK family; RSK subfamily Chromosomal Location of Human Ortholog: Xq21 Cellular Component: cytoplasm; cytosol; mitochondrion; nucleolus; nucleoplasm; nucleus Molecular Function:kinase activity; protein kinase activity; protein serine/threonine kinase activity Biological Process: central nervous system development; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; negative regulation of embryonic development; signal transduction |
NCBI Summary: | This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010] |
UniProt Code: | Q9UK32 |
NCBI GenInfo Identifier: | 11133131 |
NCBI Gene ID: | 27330 |
NCBI Accession: | Q9UK32.1 |
UniProt Secondary Accession: | Q9UK32,Q6FHX2, Q8WX28, Q9H4S6, B2R854, B7ZL90, |
UniProt Related Accession: | Q9UK32 |
Molecular Weight: | 84,093 Da |
NCBI Full Name: | Ribosomal protein S6 kinase alpha-6 |
NCBI Synonym Full Names: | ribosomal protein S6 kinase A6 |
NCBI Official Symbol: | RPS6KA6 |
NCBI Official Synonym Symbols: | RSK4; PP90RSK4 |
NCBI Protein Information: | ribosomal protein S6 kinase alpha-6 |
UniProt Protein Name: | Ribosomal protein S6 kinase alpha-6 |
UniProt Synonym Protein Names: | 90 kDa ribosomal protein S6 kinase 6; p90-RSK 6; p90RSK6; Ribosomal S6 kinase 4; RSK-4; pp90RSK4 |
Protein Family: | Ribosomal protein S6 kinase |
UniProt Gene Name: | RPS6KA6 |
UniProt Entry Name: | KS6A6_HUMAN |