RNASE3 Antibody (PACO16224)
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주문- SKU:
- PACO16224
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RNASE3 Antibody (PACO16224) |
Antibody SKU: | PACO16224 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human RNASE3 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO16224(RNASE3 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: U937 cells, Primary antibody: PACO16224(RNASE3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO16224(RNASE3 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Eosinophil Cationic Protein (ECP) also known as ribonuclease 3 is a basic protein located in the eosinophil primary matrix. In humans, the eosinophil cationic protein is encoded by the RNASE3 gene. ECP is released during degranulation of eosinophils. This protein is related to inflammation and asthma because in these cases, there are increased levels of ECP in the body. There are three glycosolated forms of ECP and consequently ECP has a range of molecular weights from 18-22 kDa |
Synonyms: | ribonuclease, RNase A family, 3 |
UniProt Protein Function: | RNASE3: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. Belongs to the pancreatic ribonuclease family. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; EC 3.1.27.-; Ribonuclease Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: extracellular space; extracellular region Molecular Function:nucleic acid binding; endonuclease activity; ribonuclease activity Biological Process: defense response to Gram-positive bacterium; innate immune response in mucosa; RNA catabolic process; antibacterial humoral response |
NCBI Summary: | The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014] |
UniProt Code: | P12724 |
NCBI GenInfo Identifier: | 147744558 |
NCBI Gene ID: | 6037 |
NCBI Accession: | P12724.2 |
UniProt Secondary Accession: | P12724,Q4VBC1, Q8WTP7, Q8WZ62, Q9GZN9, |
UniProt Related Accession: | P12724 |
Molecular Weight: | 18kDa |
NCBI Full Name: | Eosinophil cationic protein |
NCBI Synonym Full Names: | ribonuclease, RNase A family, 3 |
NCBI Official Symbol: | RNASE3 |
NCBI Official Synonym Symbols: | ECP; RNS3 |
NCBI Protein Information: | eosinophil cationic protein; RNase 3; ribonuclease 3; cytotoxic ribonuclease |
UniProt Protein Name: | Eosinophil cationic protein |
UniProt Synonym Protein Names: | Ribonuclease 3; RNase 3 |
Protein Family: | Eosinophil cationic protein |
UniProt Gene Name: | RNASE3 |
UniProt Entry Name: | ECP_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |