RBBP8 Antibody (PACO48070)
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주문- SKU:
- PACO48070
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RBBP8 Antibody (PACO48070) |
Antibody SKU: | PACO48070 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human DNA endonuclease RBBP8 protein (126-331AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human endometrial cancer using PACO48070 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human placental tissue using PACO48070 at dilution of 1:100. |
Background: | Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations. |
Synonyms: | DNA endonuclease RBBP8 (EC 3.1) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2), RBBP8, CTIP |
UniProt Protein Function: | CtIP: a transcription factor containing C2H2 zinc fingers. May modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. Interacts with CTBP, with the C-terminal (BRCT) domains of BRCA1, and with the retinoblastoma protein. Abundantly expressed in brain and the immune system and associated with immune system malignancies. Ionizing radiation induces its hyperphosphorylation and dissociation from BRCA1 in an ATM-dependent manner. |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; EC 3.1.-.- Chromosomal Location of Human Ortholog: 18q11.2 Cellular Component: nucleolus; nucleoplasm; nucleus; transcriptional repressor complex Molecular Function:damaged DNA binding; protein binding; single-stranded DNA specific endodeoxyribonuclease activity Biological Process: cell cycle checkpoint; DNA double-strand break processing; DNA repair; DNA replication; DNA synthesis during DNA repair; double-strand break repair via homologous recombination; G2/M transition DNA damage checkpoint; nucleotide-excision repair; regulation of transcription from RNA polymerase II promoter; strand displacement Disease: Jawad Syndrome; Seckel Syndrome 2 |
NCBI Summary: | The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q99708 |
NCBI GenInfo Identifier: | 116242745 |
NCBI Gene ID: | 5932 |
NCBI Accession: | Q99708.2 |
UniProt Secondary Accession: | Q99708,O75371, Q8NHQ3, A6NKN2, A8K8W6, E7ETY1, |
UniProt Related Accession: | Q99708 |
Molecular Weight: | 98,434 Da |
NCBI Full Name: | DNA endonuclease RBBP8 |
NCBI Synonym Full Names: | RB binding protein 8, endonuclease |
NCBI Official Symbol: | RBBP8 |
NCBI Official Synonym Symbols: | RIM; COM1; CTIP; JWDS; SAE2; SCKL2 |
NCBI Protein Information: | DNA endonuclease RBBP8 |
UniProt Protein Name: | DNA endonuclease RBBP8 |
UniProt Synonym Protein Names: | CtBP-interacting protein; CtIP; Retinoblastoma-binding protein 8; RBBP-8; Retinoblastoma-interacting protein and myosin-like; RIM; Sporulation in the absence of SPO11 protein 2 homolog; SAE2 |
Protein Family: | RBBP8 N-terminal-like protein |
UniProt Gene Name: | RBBP8 |
UniProt Entry Name: | COM1_HUMAN |
Antibodies |
Anti-RBBP8 Antibody (CAB10201) |
RBBP8 Antibody (PACO04895) |
RBBP8 Antibody (PACO04896) |
RBBP8 Antibody (PACO11746) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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