RBBP8 Antibody (PACO16083)
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주문- SKU:
- PACO16083
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RBBP8 Antibody (PACO16083) |
Antibody SKU: | PACO16083 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:100-1:300 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human RBBP8 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO16083(RBBP8 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16083(RBBP8 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. |
Synonyms: | retinoblastoma binding protein 8 |
UniProt Protein Function: | CtIP: a transcription factor containing C2H2 zinc fingers. May modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. Interacts with CTBP, with the C-terminal (BRCT) domains of BRCA1, and with the retinoblastoma protein. Abundantly expressed in brain and the immune system and associated with immune system malignancies. Ionizing radiation induces its hyperphosphorylation and dissociation from BRCA1 in an ATM-dependent manner. |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; EC 3.1.-.- Chromosomal Location of Human Ortholog: 18q11.2 Cellular Component: nucleolus; nucleoplasm; nucleus; transcriptional repressor complex Molecular Function:damaged DNA binding; protein binding; single-stranded DNA specific endodeoxyribonuclease activity Biological Process: cell cycle checkpoint; DNA double-strand break processing; DNA repair; DNA replication; DNA synthesis during DNA repair; double-strand break repair via homologous recombination; G2/M transition DNA damage checkpoint; nucleotide-excision repair; regulation of transcription from RNA polymerase II promoter; strand displacement Disease: Jawad Syndrome; Seckel Syndrome 2 |
NCBI Summary: | The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q99708 |
NCBI GenInfo Identifier: | 116242745 |
NCBI Gene ID: | 5932 |
NCBI Accession: | Q99708.2 |
UniProt Secondary Accession: | Q99708,O75371, Q8NHQ3, A6NKN2, A8K8W6, E7ETY1, |
UniProt Related Accession: | Q99708 |
Molecular Weight: | 98,434 Da |
NCBI Full Name: | DNA endonuclease RBBP8 |
NCBI Synonym Full Names: | RB binding protein 8, endonuclease |
NCBI Official Symbol: | RBBP8 |
NCBI Official Synonym Symbols: | RIM; COM1; CTIP; JWDS; SAE2; SCKL2 |
NCBI Protein Information: | DNA endonuclease RBBP8 |
UniProt Protein Name: | DNA endonuclease RBBP8 |
UniProt Synonym Protein Names: | CtBP-interacting protein; CtIP; Retinoblastoma-binding protein 8; RBBP-8; Retinoblastoma-interacting protein and myosin-like; RIM; Sporulation in the absence of SPO11 protein 2 homolog; SAE2 |
Protein Family: | RBBP8 N-terminal-like protein |
UniProt Gene Name: | RBBP8 |
UniProt Entry Name: | COM1_HUMAN |
Antibodies |
Anti-RBBP8 Antibody (CAB10201) |
RBBP8 Antibody (PACO04895) |
RBBP8 Antibody (PACO04896) |
RBBP8 Antibody (PACO11746) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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