PRG2 Antibody (PACO46126)
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주문- SKU:
- PACO46126
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PRG2 Antibody (PACO46126) |
Antibody SKU: | PACO46126 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Bone marrow proteoglycan protein (151-195aa) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: PRG2 antibody at 14 µg/ml + Human placenta tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 26, 24 kDa. Observed band size: 26 kDa.. | |
Immunofluorescent analysis of U251 cells using PACO46126 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human liver cancer using PACO46126 at dilution of 1:100. |
Background: | Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. |
Synonyms: | Bone marrow proteoglycan (BMPG) (Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein (EMBP) (MBP) (Pregnancy-associated major basic protein)], PRG2, MBP |
UniProt Protein Function: | PRG2: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. |
UniProt Protein Details: | Protein type:Vesicle; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11q12 Cellular Component: transport vesicle; extracellular region Molecular Function:heparin binding; carbohydrate binding Biological Process: positive regulation of interleukin-4 production; negative regulation of interleukin-10 production; defense response to bacterium; immune response; defense response to nematode |
NCBI Summary: | The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014] |
UniProt Code: | P13727 |
NCBI GenInfo Identifier: | 281185479 |
NCBI Gene ID: | 5553 |
NCBI Accession: | P13727.2 |
UniProt Secondary Accession: | P13727,P81448, Q14227, Q6ICT2, A6XMW0, B2R5I1, |
UniProt Related Accession: | P13727 |
Molecular Weight: | 25kDa |
NCBI Full Name: | Bone marrow proteoglycan |
NCBI Synonym Full Names: | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) |
NCBI Official Symbol: | PRG2 |
NCBI Official Synonym Symbols: | MBP; BMPG; MBP1 |
NCBI Protein Information: | bone marrow proteoglycan; bone-marrow proteoglycan; proteoglycan 2 preproprotein; natural killer cell activator; eosinophil major basic protein; eosinophil granule major basic protein |
UniProt Protein Name: | Bone marrow proteoglycan |
UniProt Synonym Protein Names: | Proteoglycan 2Eosinophil granule major basic protein; EMBP; MBPAlternative name(s):Pregnancy-associated major basic protein |
Protein Family: | Myelin basic protein |
UniProt Gene Name: | PRG2 |
UniProt Entry Name: | PRG2_HUMAN |
Antibodies | ELISA Kits |
Anti-PRG2 Antibody (CAB2532) | Human Bone marrow proteoglycan / PRG2 ELISA Kit |
PRG2 Antibody (PACO11460) | Human Bone marrow proteoglycan (PRG2) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |