Phospho-RACGAP1 (S387) Antibody (PACO03994)
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주문- SKU:
- PACO03994
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Reactivity:
- Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | Phospho-RACGAP1 (S387) Antibody |
Antibody SKU: | PACO03994 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
Species Reactivity: | Human, Mouse, Rat, Monkey |
Immunogen: | synthesized peptide derived from human Rac GAP1 around the phosphorylation site of S387. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | RACGAP1; KIAA1478; MGCRACGAP; Rac GTPase-activating protein 1; Male germ cell RacGap; MgcRacGAP; Protein CYK4 homolg; CYK4; HsCYK-4 |
UniProt Protein Function: | MgcRacGAP: a rac GTPase activating protein. Plays an important role in cytokinesis by regulating cortical movement through RhoA. Phosphorylation by Aurora B apparently induces GAP activity toward RhoA. |
UniProt Protein Details: | Protein type:GAPs; GAPs, Rac/Rho Chromosomal Location of Human Ortholog: 12q13.12 Cellular Component: nucleoplasm; microtubule; extrinsic to internal side of plasma membrane; acrosome; spindle midzone; midbody; nucleus; cytosol; cleavage furrow Molecular Function:gamma-tubulin binding; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; metal ion binding; microtubule binding; beta-tubulin binding; protein kinase binding; GTPase activator activity; alpha-tubulin binding Biological Process: positive regulation of cytokinesis; regulation of attachment of spindle microtubules to kinetochore; spindle midzone assembly involved in mitosis; antigen processing and presentation of exogenous peptide antigen via MHC class II; sulfate transport; microtubule-based movement; regulation of small GTPase mediated signal transduction; embryonic development; cytokinesis after mitosis; small GTPase mediated signal transduction; neuroblast proliferation; spermatogenesis; blood coagulation; cytokinesis, contractile ring formation; positive regulation of GTPase activity |
NCBI Summary: | The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011] |
UniProt Code: | Q9H0H5 |
NCBI GenInfo Identifier: | 74762727 |
NCBI Gene ID: | 29127 |
NCBI Accession: | Q9H0H5.1 |
UniProt Secondary Accession: | Q9H0H5,Q6PJ26, Q9NWN2, Q9P250, Q9P2W2, |
UniProt Related Accession: | Q9H0H5 |
Molecular Weight: | 632 |
NCBI Full Name: | Rac GTPase-activating protein 1 |
NCBI Synonym Full Names: | Rac GTPase activating protein 1 |
NCBI Official Symbol: | RACGAP1 |
NCBI Official Synonym Symbols: | CYK4; ID-GAP; HsCYK-4; MgcRacGAP |
NCBI Protein Information: | rac GTPase-activating protein 1; RACGAP1; protein CYK4 homolg; protein CYK4 homolog; male germ cell RacGap; GTPase activating protein |
UniProt Protein Name: | Rac GTPase-activating protein 1 |
UniProt Synonym Protein Names: | Male germ cell RacGap; MgcRacGAP; Protein CYK4 homolog; CYK4; HsCYK-4 |
Protein Family: | Rac GTPase-activating protein |
UniProt Gene Name: | RACGAP1 |
UniProt Entry Name: | RGAP1_HUMAN |