RACGAP1 Antibody (PACO48146)
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주문- SKU:
- PACO48146
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | RACGAP1 Antibody (PACO48146) |
Antibody SKU: | PACO48146 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Rac GTPase-activating protein 1 protein (86-331AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human thymus tissue using PACO48146 at dilution of 1:100. | |
Immunofluorescent analysis of HepG2 cells using PACO48146 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. |
Synonyms: | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4), RACGAP1, KIAA1478 MGCRACGAP |
UniProt Protein Function: | MgcRacGAP: a rac GTPase activating protein. Plays an important role in cytokinesis by regulating cortical movement through RhoA. Phosphorylation by Aurora B apparently induces GAP activity toward RhoA. |
UniProt Protein Details: | Protein type:GAPs; GAPs, Rac/Rho Chromosomal Location of Human Ortholog: 12q13.12 Cellular Component: nucleoplasm; microtubule; extrinsic to internal side of plasma membrane; acrosome; spindle midzone; midbody; nucleus; cytosol; cleavage furrow Molecular Function:gamma-tubulin binding; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; metal ion binding; microtubule binding; beta-tubulin binding; protein kinase binding; GTPase activator activity; alpha-tubulin binding Biological Process: positive regulation of cytokinesis; regulation of attachment of spindle microtubules to kinetochore; spindle midzone assembly involved in mitosis; antigen processing and presentation of exogenous peptide antigen via MHC class II; sulfate transport; microtubule-based movement; regulation of small GTPase mediated signal transduction; embryonic development; cytokinesis after mitosis; small GTPase mediated signal transduction; neuroblast proliferation; spermatogenesis; blood coagulation; cytokinesis, contractile ring formation; positive regulation of GTPase activity |
NCBI Summary: | The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011] |
UniProt Code: | Q9H0H5 |
NCBI GenInfo Identifier: | 74762727 |
NCBI Gene ID: | 29127 |
NCBI Accession: | Q9H0H5.1 |
UniProt Secondary Accession: | Q9H0H5,Q6PJ26, Q9NWN2, Q9P250, Q9P2W2, |
UniProt Related Accession: | Q9H0H5 |
Molecular Weight: | 632 |
NCBI Full Name: | Rac GTPase-activating protein 1 |
NCBI Synonym Full Names: | Rac GTPase activating protein 1 |
NCBI Official Symbol: | RACGAP1 |
NCBI Official Synonym Symbols: | CYK4; ID-GAP; HsCYK-4; MgcRacGAP |
NCBI Protein Information: | rac GTPase-activating protein 1; RACGAP1; protein CYK4 homolg; protein CYK4 homolog; male germ cell RacGap; GTPase activating protein |
UniProt Protein Name: | Rac GTPase-activating protein 1 |
UniProt Synonym Protein Names: | Male germ cell RacGap; MgcRacGAP; Protein CYK4 homolog; CYK4; HsCYK-4 |
Protein Family: | Rac GTPase-activating protein |
UniProt Gene Name: | RACGAP1 |
UniProt Entry Name: | RGAP1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |