Phospho-MEF2A (T319) Antibody (PACO06139)
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주문- SKU:
- PACO06139
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | Phospho-MEF2A (T319) Antibody (PACO06139) |
Antibody SKU: | PACO06139 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthesized peptide derived from human MEF-2 around the phosphorylation site of T319. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot analysis of VEC 293 cells using Phospho-MEF-2 (T319) Polyclonal Antibody. | |
Western Blot analysis of VEC cells using Phospho-MEF-2 (T319) Polyclonal Antibody. |
Synonyms: | MEF2A; MEF2; Myocyte-specific enhancer factor 2A; Serum response factor-like protein 1 |
UniProt Protein Function: | MEF2A: a myocyte-specific enhancing transcription factor which binds specifically to the MEF2 element present in the regulatory regions of many, if not all, muscle-specific genes. A member of the MADS gene family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain. Five alternatively spliced isoforms have been reported. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 15q26 Cellular Component: cytoplasm; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex Molecular Function:chromatin binding; histone acetyltransferase binding; histone deacetylase binding; protein binding; protein heterodimerization activity; protein kinase binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; SMAD binding; transcription activator binding; transcription factor activity Biological Process: apoptosis; dendrite morphogenesis; heart development; innate immune response; MAPKKK cascade; mitochondrial genome maintenance; mitochondrion distribution; muscle cell differentiation; muscle development; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; positive regulation of muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; transcription from RNA polymerase II promoter; transcription, DNA-dependent; ventricular cardiac myofibril development Disease: Coronary Artery Disease, Autosomal Dominant, 1 |
NCBI Summary: | The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010] |
UniProt Code: | Q02078 |
NCBI GenInfo Identifier: | 1170908 |
NCBI Gene ID: | 4205 |
NCBI Accession: | Q02078.1 |
UniProt Secondary Accession: | Q02078,O43814, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14 B4DFQ7, F6XG23, |
UniProt Related Accession: | Q02078 |
Molecular Weight: | 45,570 Da |
NCBI Full Name: | Myocyte-specific enhancer factor 2A |
NCBI Synonym Full Names: | myocyte enhancer factor 2A |
NCBI Official Symbol: | MEF2A |
NCBI Official Synonym Symbols: | mef2; ADCAD1; RSRFC4; RSRFC9 |
NCBI Protein Information: | myocyte-specific enhancer factor 2A |
UniProt Protein Name: | Myocyte-specific enhancer factor 2A |
UniProt Synonym Protein Names: | Serum response factor-like protein 1 |
Protein Family: | Myocyte-specific enhancer factor |
UniProt Gene Name: | MEF2A |
UniProt Entry Name: | MEF2A_HUMAN |
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