MEF2A Antibody (PACO62323)
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주문- SKU:
- PACO62323
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | MEF2A Antibody (PACO62323) |
Antibody SKU: | PACO62323 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:100-1:1000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Myocyte-specific enhancer factor 2A protein (72-226AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: U87 whole cell lysate, Hela whole cell lysate, MCF-7 whole cell lysate. All lanes: MEF2A antibody at 1:500. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 55, 54, 47, 46 kDa. Observed band size: 55 kDa. |
Background: | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. |
Synonyms: | Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1), MEF2A, MEF2 |
UniProt Protein Function: | MEF2A: a myocyte-specific enhancing transcription factor which binds specifically to the MEF2 element present in the regulatory regions of many, if not all, muscle-specific genes. A member of the MADS gene family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain. Five alternatively spliced isoforms have been reported. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 15q26 Cellular Component: cytoplasm; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex Molecular Function:chromatin binding; histone acetyltransferase binding; histone deacetylase binding; protein binding; protein heterodimerization activity; protein kinase binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; SMAD binding; transcription activator binding; transcription factor activity Biological Process: apoptosis; dendrite morphogenesis; heart development; innate immune response; MAPKKK cascade; mitochondrial genome maintenance; mitochondrion distribution; muscle cell differentiation; muscle development; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; positive regulation of muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; transcription from RNA polymerase II promoter; transcription, DNA-dependent; ventricular cardiac myofibril development Disease: Coronary Artery Disease, Autosomal Dominant, 1 |
NCBI Summary: | The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010] |
UniProt Code: | Q02078 |
NCBI GenInfo Identifier: | 1170908 |
NCBI Gene ID: | 4205 |
NCBI Accession: | Q02078.1 |
UniProt Secondary Accession: | Q02078,O43814, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14 B4DFQ7, F6XG23, |
UniProt Related Accession: | Q02078 |
Molecular Weight: | 45,570 Da |
NCBI Full Name: | Myocyte-specific enhancer factor 2A |
NCBI Synonym Full Names: | myocyte enhancer factor 2A |
NCBI Official Symbol: | MEF2A |
NCBI Official Synonym Symbols: | mef2; ADCAD1; RSRFC4; RSRFC9 |
NCBI Protein Information: | myocyte-specific enhancer factor 2A |
UniProt Protein Name: | Myocyte-specific enhancer factor 2A |
UniProt Synonym Protein Names: | Serum response factor-like protein 1 |
Protein Family: | Myocyte-specific enhancer factor |
UniProt Gene Name: | MEF2A |
UniProt Entry Name: | MEF2A_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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