Phospho-FOXO4 (S262) Antibody (PACO04343)
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주문- SKU:
- PACO04343
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | Phospho-FOXO4 (S262) Antibody |
Antibody SKU: | PACO04343 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
Species Reactivity: | Human, Mouse |
Immunogen: | synthesized peptide derived from human FoxO4 around the phosphorylation site of S262. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | FOXO4; AFX; AFX1; MLLT7; Forkhead box protein O4; Fork head domain transcription factor AFX1 |
UniProt Protein Function: | FOXO4: transcription factor AFX1 containing 1 fork-head domain. May play a role in the insulin signaling pathway. Involved in acute leukemias by a chromosomal translocation t(X;11)(q13;q23) that involves MLLT7 and MLL/HRX. The result is a rogue activator protein. Two splice-variant isoforms have been described. |
UniProt Protein Details: | Protein type:Oncoprotein; Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: Xq13.1 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:beta-catenin binding; DNA binding; enzyme binding; identical protein binding; protein binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding Biological Process: cell cycle arrest; insulin receptor signaling pathway; negative regulation of angiogenesis; negative regulation of cell proliferation; negative regulation of smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; stem cell differentiation; transcription from RNA polymerase II promoter |
NCBI Summary: | This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] |
UniProt Code: | P98177 |
NCBI GenInfo Identifier: | 110825720 |
NCBI Gene ID: | 4303 |
NCBI Accession: | P98177.5 |
UniProt Secondary Accession: | P98177,O43821, Q13720, Q3KPF1, Q8TDK9, B7WPJ7, |
UniProt Related Accession: | P98177 |
Molecular Weight: | 47,941 Da |
NCBI Full Name: | Forkhead box protein O4 |
NCBI Synonym Full Names: | forkhead box O4 |
NCBI Official Symbol: | FOXO4 |
NCBI Official Synonym Symbols: | AFX; AFX1; MLLT7 |
NCBI Protein Information: | forkhead box protein O4 |
UniProt Protein Name: | Forkhead box protein O4 |
UniProt Synonym Protein Names: | Fork head domain transcription factor AFX1 |
Protein Family: | Forkhead box protein |
UniProt Gene Name: | FOXO4 |
UniProt Entry Name: | FOXO4_HUMAN |