Phospho-CSK (S364) Antibody (PACO02489)
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주문- SKU:
- PACO02489
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | Phospho-CSK (S364) Antibody |
Antibody SKU: | PACO02489 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from human Csk around the phosphorylation site of S364. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | CSK; Tyrosine-protein kinase CSK; C-Src kinase; Protein-tyrosine kinase CYL |
UniProt Protein Function: | CSK: a tyrosine kinase of the Csk family that phosphorylates and inhibits Src family kinases. Specifically phosphorylates Y504 on LCK, which acts as a negative regulatory site. Csk and the phospho-tyrosine phosphatase CD45 reciprocally regulate phosphorylation of the inhibitory tyrosine of the Src family kinases Lck and Fyn during T-cell receptor mediated signaling during thymic development. |
UniProt Protein Details: | Protein type:Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Protein kinase, TK; Kinase, protein; TK group; Csk family Chromosomal Location of Human Ortholog: 15q24.1 Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; plasma membrane Molecular Function:identical protein binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; protein binding; protein C-terminus binding; protein-tyrosine kinase activity; receptor binding Biological Process: cell differentiation; cell migration; central nervous system development; epidermal growth factor receptor signaling pathway; innate immune response; negative regulation of Golgi to plasma membrane protein transport; protein amino acid phosphorylation; regulation of cell proliferation; regulation of cytokine production; T cell costimulation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway |
UniProt Code: | P41240 |
NCBI GenInfo Identifier: | 729887 |
NCBI Gene ID: | 1445 |
NCBI Accession: | P41240.1 |
UniProt Secondary Accession: | P41240,Q2M3N2, Q6FGZ6, |
UniProt Related Accession: | P41240 |
Molecular Weight: | 50,704 Da |
NCBI Full Name: | Tyrosine-protein kinase CSK |
NCBI Synonym Full Names: | c-src tyrosine kinase |
NCBI Official Symbol: | CSK |
NCBI Protein Information: | tyrosine-protein kinase CSK |
UniProt Protein Name: | Tyrosine-protein kinase CSK |
UniProt Synonym Protein Names: | C-Src kinase; Protein-tyrosine kinase CYL |
Protein Family: | Chloroplast sensor kinase |
UniProt Gene Name: | CSK |
UniProt Entry Name: | CSK_HUMAN |