PGC Antibody (PACO14872)
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주문- SKU:
- PACO14872
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PGC Antibody (PACO14872) |
Antibody SKU: | PACO14872 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human PGC |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14872(PGC Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 12%SDS-PAGE, Lysate: 50 μg, Lane: 823 cells, Primary antibody: PACO14872(PGC Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO14872(PGC Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. |
Synonyms: | progastricsin (pepsinogen C) |
UniProt Protein Function: | PGC: Hydrolyzes a variety of proteins. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Protease; Secreted; EC 3.4.23.3 Chromosomal Location of Human Ortholog: 6p21.1 Cellular Component: extracellular space Molecular Function:aspartic-type endopeptidase activity Biological Process: digestion; proteolysis |
NCBI Summary: | This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009] |
UniProt Code: | P20142 |
NCBI GenInfo Identifier: | 129796 |
NCBI Gene ID: | 5225 |
NCBI Accession: | P20142.1 |
UniProt Secondary Accession: | P20142,Q5T3D7, Q5T3D8, B4DVZ3, |
UniProt Related Accession: | P20142 |
Molecular Weight: | 40,600 |
NCBI Full Name: | Gastricsin |
NCBI Synonym Full Names: | progastricsin (pepsinogen C) |
NCBI Official Symbol: | PGC |
NCBI Official Synonym Symbols: | PEPC; PGII |
NCBI Protein Information: | gastricsin; pepsin C; pepsinogen C; preprogastricsin; pepsinogen group II |
UniProt Protein Name: | Gastricsin |
UniProt Synonym Protein Names: | Pepsinogen C |
Protein Family: | Gastricsin |
UniProt Gene Name: | PGC |
UniProt Entry Name: | PEPC_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |