NKX3-2 Antibody (PACO55682)
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주문- SKU:
- PACO55682
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NKX3-2 Antibody (PACO55682) |
Antibody SKU: | PACO55682 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
Species Reactivity: | Human, Rat |
Immunogen: | Recombinant Human Homeobox protein Nkx-3.2 protein (1-333AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Rat brain tissue. All lanes: NKX3-2 antibody at 4.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 35 kDa. Observed band size: 35 kDa. |
Background: | Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity). |
Synonyms: | Homeobox protein Nkx-3.2 (Bagpipe homeobox protein homolog 1) (Homeobox protein NK-3 homolog B), NKX3-2, BAPX1 NKX3B |
UniProt Protein Function: | NKX3-2: Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus. Defects in NKX3-2 are the cause of spondylo- megaepiphyseal-metaphyseal dysplasia (SMMD). It is a skeletal dysplasia characterized by disproportionate short stature with a short and stiff neck and trunk, relatively long limbs that may show flexion contractures of the distal joints, delayed and impaired ossification of the vertebral bodies, the presence of large epiphysea ossification centers and wide growth plates in the long tubular bones and numerous pseudoepiphyses of the short tubular bones in hands and feet. Belongs to the NK-3 homeobox family. |
UniProt Protein Details: | Protein type:DNA-binding; Cell development/differentiation; Transcription factor Chromosomal Location of Human Ortholog: 4p16.3 Biological Process: negative regulation of chondrocyte differentiation; skeletal development; transcription from RNA polymerase II promoter Disease: Spondylo-megaepiphyseal-metaphyseal Dysplasia |
NCBI Summary: | This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development. [provided by RefSeq, Jul 2008] |
UniProt Code: | P78367 |
NCBI GenInfo Identifier: | 6016210 |
NCBI Gene ID: | 579 |
NCBI Accession: | P78367.2 |
UniProt Secondary Accession: | P78367,Q2M2I7, |
UniProt Related Accession: | P78367 |
Molecular Weight: | 34,814 Da |
NCBI Full Name: | Homeobox protein Nkx-3.2 |
NCBI Synonym Full Names: | NK3 homeobox 2 |
NCBI Official Symbol: | NKX3-2 |
NCBI Official Synonym Symbols: | SMMD; BAPX1; NKX3B; NKX3.2 |
NCBI Protein Information: | homeobox protein Nkx-3.2 |
UniProt Protein Name: | Homeobox protein Nkx-3.2 |
UniProt Synonym Protein Names: | Bagpipe homeobox protein homolog 1; Homeobox protein NK-3 homolog B |
Protein Family: | Homeobox protein |
UniProt Gene Name: | NKX3-2 |
UniProt Entry Name: | NKX32_HUMAN |
Antibodies |
Anti-NKX3-2 Antibody (CAB8093) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |