NFKBIA (Ab-32/36) Antibody (PACO23048)
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주문- SKU:
- PACO23048
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NFKBIA (Ab-32/36) Antibody (PACO23048) |
Antibody SKU: | PACO23048 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthesized non-phosphopeptide derived from human I kappa B- alpha around the phosphorylation site of Serine 32/36. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from MCF7 cells, treated with TNF-alpha , using IkappaB-alpha (Ab-32/36) antibody. | |
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using IkappaB-alpha (Ab-32/36) antibody. |
Background: | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
Synonyms: | I-kappa-B-alpha; IkappaBalpha; IKBA; MAD3; Major histocompatibility complex enhancer-binding protein MAD3 |
UniProt Protein Function: | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
NCBI Summary: | This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011] |
UniProt Code: | P25963 |
NCBI GenInfo Identifier: | 126682 |
NCBI Gene ID: | 4792 |
NCBI Accession: | P25963.1 |
UniProt Secondary Accession: | P25963,B2R8L6, |
UniProt Related Accession: | P25963 |
Molecular Weight: | 35,609 Da |
NCBI Full Name: | NF-kappa-B inhibitor alpha |
NCBI Synonym Full Names: | NFKB inhibitor alpha |
NCBI Official Symbol: | NFKBIA |
NCBI Official Synonym Symbols: | IKBA; MAD-3; NFKBI |
NCBI Protein Information: | NF-kappa-B inhibitor alpha |
UniProt Protein Name: | NF-kappa-B inhibitor alpha |
UniProt Synonym Protein Names: | I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3 |
Protein Family: | NF-kappa-B inhibitor |
UniProt Gene Name: | NFKBIA |
UniProt Entry Name: | IKBA_HUMAN |
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