NFKBIA Antibody (PACO13937)
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주문- SKU:
- PACO13937
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NFKBIA Antibody (PACO13937) |
Antibody SKU: | PACO13937 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human NFKBIA |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hela cells, Jurkat cells, 293T cells, K562 cells, Primary antibody: PACO13937(NFKBIA Antibody) at dilution 1/84, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
Background: | This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. |
Synonyms: | nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor, alpha |
UniProt Protein Function: | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
NCBI Summary: | This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011] |
UniProt Code: | P25963 |
NCBI GenInfo Identifier: | 126682 |
NCBI Gene ID: | 4792 |
NCBI Accession: | P25963.1 |
UniProt Secondary Accession: | P25963,B2R8L6, |
UniProt Related Accession: | P25963 |
Molecular Weight: | 35,609 Da |
NCBI Full Name: | NF-kappa-B inhibitor alpha |
NCBI Synonym Full Names: | NFKB inhibitor alpha |
NCBI Official Symbol: | NFKBIA |
NCBI Official Synonym Symbols: | IKBA; MAD-3; NFKBI |
NCBI Protein Information: | NF-kappa-B inhibitor alpha |
UniProt Protein Name: | NF-kappa-B inhibitor alpha |
UniProt Synonym Protein Names: | I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3 |
Protein Family: | NF-kappa-B inhibitor |
UniProt Gene Name: | NFKBIA |
UniProt Entry Name: | IKBA_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |