NEK4 Antibody (PACO19207)
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주문- SKU:
- PACO19207
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NEK4 Antibody (PACO19207) |
Antibody SKU: | PACO19207 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human NEK4 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO19207(NEK4 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO19207(NEK4 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | NIMA was originally shown in Aspergillus nidulans to be necessary for entry into mitosis. NIMA-related mammalian proteins have since been identified as Nek1, Nek2, Nek3 and Nek4 (also designated STK2 or NRK2). High expression of Nek1 is seen in male and female germ cell lines of mouse. Nek2 is the closest known mammalian relative to NIMA. Like NIMA, Nek2 expression peaks at the G2 to M phase transition. Nek3 is a predominantly cytoplasmic enzyme that was detectable in all organs studied. Levels of Nek3 seem to remain unchanged throughout the cell cycle, but appear to be elevated in G0-arrested, quiescent fibroblasts. In developing testicular germ cells, differential patterns of expression were seen for Nek1, Nek2 and Nek4, indicating possible overlapping, but non-identical functions. |
Synonyms: | NIMA-related kinase 4 |
UniProt Protein Function: | NEK4: a protein kinase of the NEK family. Highly conserved between the mouse and human and expressed at high levels in the testis. |
UniProt Protein Details: | Protein type:Protein kinase, Other; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Other group; NEK family Chromosomal Location of Human Ortholog: 3p21.1 Cellular Component: cytoplasm; cilium Molecular Function:protein serine/threonine kinase activity; manganese ion binding; ATP binding; receptor signaling protein serine/threonine kinase activity Biological Process: mitosis; cell division; mitotic cell cycle; protein amino acid phosphorylation; response to DNA damage stimulus |
UniProt Code: | P51957 |
NCBI GenInfo Identifier: | 116283241 |
NCBI Gene ID: | 6787 |
NCBI Accession: | |
UniProt Related Accession: | P51957,Q05DF6 |
Molecular Weight: | 50,822 Da |
NCBI Full Name: | NEK4 protein |
NCBI Synonym Full Names: | NIMA (never in mitosis gene a)-related kinase 4 |
NCBI Official Symbol: | NEK4 |
NCBI Official Synonym Symbols: | NRK2; STK2; pp12301; MGC33171 |
NCBI Protein Information: | serine/threonine-protein kinase Nek4; OTTHUMP00000213580; OTTHUMP00000213581; OTTHUMP00000213582; serine/threonine kinase 2; nimA-related protein kinase 4; serine/threonine protein kinase-2; serine/threonine-protein kinase 2; never in mitosis A-related kinase 4; serine/threonine-protein kinase NRK2 |
UniProt Protein Name: | NEK4 protein |
Protein Family: | Serine/threonine-protein kinase |
UniProt Gene Name: | NEK4 |
UniProt Entry Name: | Q05DF6_HUMAN |