MDH1 Antibody (PACO16664)
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주문- SKU:
- PACO16664
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MDH1 Antibody (PACO16664) |
Antibody SKU: | PACO16664 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human MDH1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 60 μg, Lane: Hela cells, Primary antibody: PACO16664(MDH1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
Background: | Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid, cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
Synonyms: | malate dehydrogenase 1, NAD (soluble) |
UniProt Protein Function: | MDH1: Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Nov 2010] |
UniProt Protein Details: | Protein type:EC 1.1.1.96; Carbohydrate Metabolism - pyruvate; Oxidoreductase; Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.37; Carbohydrate Metabolism - glyoxylate and dicarboxylate Chromosomal Location of Human Ortholog: 2p13.3 Cellular Component: centrosome; extracellular space; mitochondrion; cytoplasm; cytosol Molecular Function:malic enzyme activity; L-malate dehydrogenase activity; diiodophenylpyruvate reductase activity; NAD binding Biological Process: malate metabolic process; oxaloacetate metabolic process; NADH metabolic process; tricarboxylic acid cycle; carbohydrate metabolic process; glucose metabolic process; cellular carbohydrate metabolic process; pathogenesis; gluconeogenesis |
NCBI Summary: | This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6. [provided by RefSeq, Feb 2016] |
UniProt Code: | P40925 |
NCBI GenInfo Identifier: | 1708967 |
NCBI Gene ID: | 4190 |
NCBI Accession: | P40925.4 |
UniProt Related Accession: | P40925 |
Molecular Weight: | ~ 36kDa |
NCBI Full Name: | Malate dehydrogenase, cytoplasmic |
NCBI Synonym Full Names: | malate dehydrogenase 1 |
NCBI Official Symbol: | MDH1 |
NCBI Official Synonym Symbols: | MDHA; MOR2; MDH-s; HEL-S-32; MGC:1375 |
NCBI Protein Information: | malate dehydrogenase, cytoplasmic; malate dehydrogenase, peroxisomal |
UniProt Protein Name: | Malate dehydrogenase, cytoplasmic |
UniProt Synonym Protein Names: | Cytosolic malate dehydrogenase; Diiodophenylpyruvate reductase (EC:1.1.1.96) |
Protein Family: | Malate dehydrogenase |
UniProt Gene Name: | MDH1 |
UniProt Entry Name: | MDHC_HUMAN |
Antibodies | ELISA Kits |
Anti-MDH1 Antibody (CAB7563) | Human Malate dehydrogenase, cytoplasmic (MDH1) ELISA Kit |
MDH1 Antibody (PACO10429) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |