KRT18 (Ab-33) Antibody (PACO22979)
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주문- SKU:
- PACO22979
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | KRT18 (Ab-33) Antibody (PACO22979) |
Antibody SKU: | PACO22979 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:1000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Peptide sequence around aa.31~35 (A-A-S-V-Y) derived from Human Keratin 18 (CK18). |
Form: | Liquid |
Storage Buffer: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from 293 cells using Keratin 18(Ab-33) Antibody. | |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Keratin 18(Ab-33) Antibody(left) or the same antibody preincubated with blocking peptide(right). |
Background: | KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. utations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. |
Synonyms: | CK 18; CK18; CYK18; Cytokeratin endo B; K18 |
UniProt Protein Function: | K18: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 18 and its filament partner keratin 8 are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Defects are a cause of cryptogenic cirrhosis. |
UniProt Protein Details: | Protein type:Nucleolus; Cytoskeletal Chromosomal Location of Human Ortholog: 12q13 Cellular Component: cytoplasm; intermediate filament; keratin filament; microtubule organizing center; nucleolus; perinuclear region of cytoplasm Molecular Function:protein binding; structural molecule activity Biological Process: anatomical structure morphogenesis; cell cycle; Golgi to plasma membrane CFTR protein transport; intermediate filament cytoskeleton organization and biogenesis; negative regulation of apoptosis; tumor necrosis factor-mediated signaling pathway; viral reproduction Disease: Cirrhosis, Familial |
NCBI Summary: | KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P05783 |
NCBI GenInfo Identifier: | 125083 |
NCBI Gene ID: | 3875 |
NCBI Accession: | P05783.2 |
UniProt Secondary Accession: | P05783,Q53G38, Q5U0N8, Q9BW26, |
UniProt Related Accession: | P05783 |
Molecular Weight: | |
NCBI Full Name: | Keratin, type I cytoskeletal 18 |
NCBI Synonym Full Names: | keratin 18 |
NCBI Official Symbol: | KRT18 |
NCBI Official Synonym Symbols: | K18; CK-18; CYK18 |
NCBI Protein Information: | keratin, type I cytoskeletal 18 |
UniProt Protein Name: | Keratin, type I cytoskeletal 18 |
UniProt Synonym Protein Names: | Cell proliferation-inducing gene 46 protein; Cytokeratin-18; CK-18; Keratin-18; K18 |
Protein Family: | Keratin |
UniProt Gene Name: | KRT18 |
UniProt Entry Name: | K1C18_HUMAN |
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