KARS Antibody (PACO16576)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO16576
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | KARS Antibody (PACO16576) |
Antibody SKU: | PACO16576 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human KARS |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO16576(KARS Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16576(KARS Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acid, . Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Synonyms: | lysyl-tRNA synthetase |
UniProt Protein Function: | KARS: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of diadenosine oligophosphate (Ap4A), a signaling molecule involved in the activation of MITF transcriptional activity. Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation. Homodimer; also part of a multisubunit complex that groups AIMP1, AIMP2, EEF1A1 and tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro. Interacts with AIMP2 (via N- terminus) and MITF. Interacts directly with HIV-1 virus GAG protein. Up-regulated by DARS and EEF1A1, but not by AIMP2. Belongs to the class-II aminoacyl-tRNA synthetase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Mitochondrial; EC 6.1.1.6; Translation; Ligase Chromosomal Location of Human Ortholog: 16q23.1 Cellular Component: cytoplasm; cytosol; microtubule cytoskeleton; mitochondrial matrix; mitochondrion Molecular Function:lysine-tRNA ligase activity; protein binding Biological Process: lysyl-tRNA aminoacylation; tRNA aminoacylation for protein translation Disease: Charcot-marie-tooth Disease, Recessive Intermediate B; Deafness, Autosomal Recessive 89 |
NCBI Summary: | Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q15046 |
NCBI GenInfo Identifier: | 20178333 |
NCBI Gene ID: | 3735 |
NCBI Accession: | Q15046.3 |
UniProt Secondary Accession: | Q15046,O14946, Q96J25, Q9HB23, A8MSK1, D3DUK4, |
UniProt Related Accession: | Q15046 |
Molecular Weight: | 71,497 Da |
NCBI Full Name: | Lysine--tRNA ligase |
NCBI Synonym Full Names: | lysyl-tRNA synthetase |
NCBI Official Symbol: | KARS |
NCBI Official Synonym Symbols: | KRS; KARS1; KARS2; CMTRIB; DFNB89 |
NCBI Protein Information: | lysine--tRNA ligase |
UniProt Protein Name: | Lysine--tRNA ligase |
UniProt Synonym Protein Names: | Lysyl-tRNA synthetase; LysRS |
UniProt Gene Name: | KARS |
UniProt Entry Name: | SYK_HUMAN |
Antibodies | ELISA Kits |
Anti-KARS Antibody (CAB13772) | Human Lysyl-tRNA synthetase (KARS) ELISA Kit |
KARS Antibody (PACO10037) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |