Human TRAIL/TNFSF10 Recombinant Protein (RPES1077)

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SKU:
RPES1077
Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
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Description

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Human TRAIL/TNFSF10 Recombinant Protein

Human TNFSF10 is a type II transmembrane protein with an intracellular N-terminus and a ‘TNF homology domain’ (THD) at the extracellular C terminus. TNFSF10 can interact with several distinct receptors. Two of these receptors that belongs to TNFR superfamily, DR4 (TRAIL-R1) and DR5 (TRAIL-R2/TRICK2), are plasma membrane proteins containing intracellular death domains essential for activating apoptosis. TNFSF10 is promising for cancer therapy because it is cytotoxic and activates apoptosis in the majority of malignant cells, but not in normal cells.

Product Name:Human TRAIL/TNFSF10 Recombinant Protein (RPES1077)
Product Code:RPES1077
Size:10µg
Species:Human
Expressed Host:E.coli
Synonyms:Tumor Necrosis Factor Ligand Superfamily Member 10, Apo-2 Ligand, Apo-2L, TNF-Related Apoptosis-Inducing Ligand, Protein TRAIL, CD253, TNFSF10, APO2L, TRAIL
Accession:Q6IBA9
Sequence:Val114-Gly281
Fusion tag:C-6His
Activity:Measured in a cytotoxicity assay using L?929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is 5-50 ng/ml.
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human TNF-related Apoptosis-inducing Ligand is produced by our E.coli expression system and the target gene encoding Val114-Gly281 is expressed with a 6His tag at the C-terminus.
Purity:> 90 % as determined by reducing SDS-PAGE.
Mol Mass:20.6 kDa
AP Mol Mass:18 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM PB?150mM NaCl,pH7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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