Human TPH2 Recombinant Protein (RPES1506)

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SKU:
RPES1506
Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
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Description

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Human TPH2 Recombinant Protein

Tryptophan 5-hydroxylase 2 (TPH2) is an isozyme member of the biopterin-dependent aromatic amino acid hydroxylase family. TPH2 is primarily expressed in the serotonergic neurons of the brain, with the highest expression found in the raphe nucleus of the midbrain. TPH2 catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD). Defects in TPH2 are the cause of psychiatric diseases such as bipolar affective disorder and major depression.

Product Name:Human TPH2 Recombinant Protein (RPES1506)
Product Code:RPES1506
Size:10µg
Species:Human
Expressed Host:E.coli
Synonyms:Tryptophan 5-Hydroxylase 2, Neuronal Tryptophan Hydroxylase, Tryptophan 5-Monooxygenase 2, TPH2, NTPH
Accession:Q14CC5
Sequence:Met 1-Ile496
Fusion tag:N-6His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Tryptophan 5-Hydroxylase 2 is produced by our E.coli expression system and the target gene encoding Met1-Ile496 is expressed with a 6His tag at the N-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:58.8 kDa
AP Mol Mass:60 kDa
Formulation:Supplied as a 0.2 µm filtered solution of 20mM PB?150mM NaCl,pH7.4.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stability and Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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