The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD140b, also known as PDGFRB, is a member of the CD system. CD140b is a cell surface tyrosine kinase receptor essencial for development interacting with the platelet-derived growth factors (PDGFs) which serves as mitogens for mesenchymal cells. CD140b can bind with platelet-derived growth factor (PDGF)-B, that are secreted by tumors and phosphorylation of PDGFR-β was correlated with depth of cancer invasion at statistically significant level.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Product Name:
Human PDGFRB/CD140b Recombinant Protein (RPES2412)
Measured by its binding ability in a functional ELISA. Immobilized human PDGFR? at 10 µg/ml (100 ?l/well) can bind Cynomolgus PDGFB , The EC50 of Cynomolgus PDGFB is 3-7 ng/ml.
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the extracellular domain of human PDGFR? (NP_002600.1) (Met 1-Lys 531) was expressed with six amino acids (ENLYFQ) at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
57.1 kDa
AP Mol Mass:
92-116 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
system_update_alt데이터시트Human PDGFRB/CD140b Recombinant Protein Platelet-Derived Growth Factor Receptor β (PDGFR-β) is a member of the protein kinase superfamily and CSF-1/PDGF receptor s
system_update_alt데이터시트Human PDGFRB/CD140b Recombinant Protein The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the imm
system_update_alt데이터시트Rat PDGFRB/CD140b Recombinant Protein The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immun
