Human N-Glycosylase/OGG1 Recombinant Protein (RPES0472)

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SKU:
RPES0472
Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
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Description

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Human N-Glycosylase/OGG1 Recombinant Protein

Human N-Glycosylase/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damage DNA. It has a β-lyase activity that nicks DNA 3’ to the lesion. OOG1 together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. The OGG1 gene mutations may be caused Renal cell carcinoma.

Product Name:Human N-Glycosylase/OGG1 Recombinant Protein (RPES0472)
Product Code:RPES0472
Size:10µg
Species:Human
Expressed Host:E.coli
Synonyms:N-Glycosylase/DNA Lyase, 8-Oxoguanine DNA Glycosylase, DNA-(Apurinic or Apyrimidinic Site) Lyase, AP Lyase, OGG1, MMH, MUTM, OGH1
Accession:O15527
Sequence:Met 1-Gly345
Fusion tag:N-GST
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human N-Glycosylase is produced by our E.coli expression system and the target gene encoding Met1-Gly345 is expressed with a GST tag at the N-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:65.1 kDa
AP Mol Mass:66 kDa
Formulation:Supplied as a 0.2 µm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stability and Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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