Human MAN1B1 Recombinant Protein (RPES3201)

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SKU:
RPES3201
Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
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Human MAN1B1 Recombinant Protein

Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-?-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.

Product Name:Human MAN1B1 Recombinant Protein (RPES3201)
Product Code:RPES3201
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-Alpha-Mannosidase, ER Alpha-1,2-Mannosidase, ER Mannosidase 1, ERMan1, Man9GlcNAc2-Specific-Processing Alpha-Mannosidase, Mannosidase Alpha Class 1B Member 1, MAN1B1
Accession:Q9UKM7
Sequence:Asp106-Ala699
Fusion tag:C-6His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-?-Mannosidase/MAN1B1 is produced by our Mammalian expression system and the target gene encoding Asp106-Ala699 is expressed with a 6His tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:68.7 kDa
AP Mol Mass:68 kDa
Formulation:Supplied as a 0.2 µm filtered solution of 50mM TrisHCL,10mM reduced Glutathione,pH 8.0.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stability and Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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