Human LRP10 Recombinant Protein (RPES0577)

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SKU:
RPES0577
Product type:
Recombinant Protein
Host species:
HEK293 Cells
Reactivity:
Human
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Description

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Human LRP10 Recombinant Protein

Various members of the low-density lipoprotein receptor (LDLR) family have been reported to play a role in APP trafficking and processing and are important risk factors in AD.LDLR-related protein 1 (LRP1) shuttles between the trans-Golgi Network (TGN); plasma membrane (PM); and endosomes.LRP1 is a functional APP receptor involved in APP trafficking and processing. LRP1 interacts directly with the ectodomain of APP and colocalizes with APP at the TGN. LRP1 is a novel APP sorting receptor that protects APP from amyloidogenic processing; suggesting that a decrease in LRP1 function may contribute to the pathogenesis of Alzheimer's disease.

Product Name:Human LRP10 Recombinant Protein (RPES0577)
Product Code:RPES0577
Size:20µg
Species:Human
Expressed Host:HEK293 Cells
Synonyms:LRP9,MST087,MSTP087
Accession:Q7Z4F1-1
Sequence:Met 1-Lys 440
Fusion tag:C-Fc
Endotoxin:<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:A DNA sequence encoding the human LRP10 (Q7Z4F1-1) extracellular domain (Met 1-Lys 440) was fused with the Fc region of human IgG1 at the C-terminus.
Purity:> 88 % as determined by reducing SDS-PAGE.
Mol Mass:73 kDa
AP Mol Mass:80-90 kDa
Formulation:Lyophilized from sterile PBS; pH 7.4
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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