Human GITRL/TNFSF18 Recombinant Protein (RPES4885)
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주문- SKU:
- RPES4885
- Product type:
- Recombinant Protein
- Host species:
- Human Cells
- Reactivity:
- Human
Frequently bought together:
Description
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Human GITRL/TNFSF18 Recombinant Protein
TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation of NF-kappa-B. As Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. It also regulates migration of monocytes from the splenic reservoir to sites of inflammation.
| Product Name: | Human GITRL/TNFSF18 Recombinant Protein (RPES4885) |
| Product Code: | RPES4885 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Tumor necrosis factor ligand superfamily member 18,TNFSF18,Activation-inducible TNF-related ligand,Glucocorticoid-induced TNF-related ligand,AITRL, GITRL, TL6 |
| Accession: | Q9UNG2 |
| Sequence: | Glu74-Ser199 |
| Fusion tag: | C-6His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Glucocorticoid Induced TNF Receptor Family Related Gene Ligand is produced by our Mammalian expression system and the target gene encoding Glu74-Ser199 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 90 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 15.3 kDa |
| AP Mol Mass: | 16 &18 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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