Human CKS1B Recombinant Protein (RPPB3190)

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SKU:
RPPB3190
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
CKS1B
Synonyms:
CDC28 Protein Kinase Regulatory Subunit 1B
Synonyms:
CDC28 Protein Kinase 1B
Synonyms:
Cyclin-Dependent Kinases Regulatory Subunit 1
Synonyms:
NB4 Apoptosis/Differentiation Related Protein
Source:
Escherichia Coli
Uniprot:
P61024
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Description

Product Name:Human CKS1B Recombinant Protein
Product Code:RPPB3190
Size:20µg
Species:Human
Target:CKS1B
Synonyms:CDC28 Protein Kinase Regulatory Subunit 1B, CDC28 Protein Kinase 1B, Cyclin-Dependent Kinases Regulatory Subunit 1, NB4 Apoptosis/Differentiation Related Protein, CDC2-Associated Protein CKS1, Cell Division Control Protein CKS1, CDC28 Protein Kinase 1, PNAS-143, PNAS-16, PNAS-18, CKS-1, ckshs1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The CKS1B solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 150mM NaCl and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSHKQIY YSDKYDDEEF EYRHVMLPKD IAKLVPKTHL MSESEWRNLG VQQSQGWVHY MIHEPEPHIL LFRRPLPKKP KK

CKS1B protein which binds to the catalytic subunit of cyclin dependent kinases is vital for their biological function. The CKS1B mRNA is expressed in HeLa cells during the course of cell cycle in several forms which suggests that the encoded protein has a particular function. Two transcript variants were identified for this gene however it seems that only one of them encodes a protein.

CKS1B Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 102 amino acids (1-79) and having a molecular mass of 12.0 kDa. CKS1B is fused to a 23 amino acid His-tag at N-terminus.

UniProt Protein Function:CKS1: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. Belongs to the CKS family.
UniProt Protein Details:

Protein type:Protein kinase, regulatory subunit; Cell cycle regulation

Chromosomal Location of Human Ortholog: 1q21.2

Cellular Component: nucleoplasm

Molecular Function:protein binding; cyclin-dependent protein kinase regulator activity

Biological Process: cell proliferation; cell division; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; G1/S transition of mitotic cell cycle

NCBI Summary:CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008]
UniProt Code:P61024
NCBI GenInfo Identifier:46577579
NCBI Gene ID:1163
NCBI Accession:P61024.1
UniProt Secondary Accession:P61024,P33551,
UniProt Related Accession:P61024
Molecular Weight:79
NCBI Full Name:Cyclin-dependent kinases regulatory subunit 1
NCBI Synonym Full Names:CDC28 protein kinase regulatory subunit 1B
NCBI Official Symbol:CKS1B  
NCBI Official Synonym Symbols:CKS1; ckshs1; PNAS-16; PNAS-18  
NCBI Protein Information:cyclin-dependent kinases regulatory subunit 1; CKS-1; PNAS-143; CDC28 protein kinase 1; CDC28 protein kinase 1B; CDC2-associated protein CKS1; cell division control protein CKS1; NB4 apoptosis/differentiation related protein
UniProt Protein Name:Cyclin-dependent kinases regulatory subunit 1
UniProt Gene Name:CKS1B  
UniProt Entry Name:CKS1_HUMAN
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