Human BDNF Recombinant Protein (RPES0401)

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SKU:
RPES0401
Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
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Description

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Human BDNF Recombinant Protein

The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis; whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival; growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects; Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.

Product Name:Human BDNF Recombinant Protein (RPES0401)
Product Code:RPES0401
Size:10µg
Species:Human
Expressed Host:E.coli
Synonyms:Brain-Derived Neurotrophic Factor, BDNF, Abrineurin
Accession:P23560
Sequence:Ala19-Arg247
Activity:Immobilized Human pro-BDNF at 2ug/ml(100 ?l/well) can bind Human TrkB-His(Cat: PKSH033579). The ED50 of Human pro-BDNF is 1.4 ug/ml .
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human BDNF is produced by our E.coli expression system and the target gene encoding Ala19-Arg247 is expressed.
Purity:> 95% as determined by reducing SDS-PAGE.
Mol Mass:25.9 kDa
AP Mol Mass:28 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM PB; 250mM NaCl; pH 7.2.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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