HLA-DOA Antibody (PACO44503)
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주문- SKU:
- PACO44503
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | HLA-DOA Antibody (PACO44503) |
Antibody SKU: | PACO44503 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human HLA class II histocompatibility antigen, DO α chain protein (26-135AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO44503 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human skin tissue using PACO44503 at dilution of 1:100. |
Background: | Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM. |
Synonyms: | HLA class II histocompatibility antigen, DO α chain (MHC DN-alpha) (MHC DZ alpha) (MHC class II antigen DOA), HLA-DOA, HLA-DNA HLA-DZA |
UniProt Protein Function: | HLA-DOA: Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM. Belongs to the MHC class II family. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: endosome membrane; integral to membrane; lysosomal membrane; MHC class II protein complex; plasma membrane Molecular Function:MHC class II receptor activity; protein binding Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; immune response; negative regulation of antigen processing and presentation of peptide antigen via MHC class II; regulation of T cell differentiation; signal transduction |
NCBI Summary: | HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008] |
UniProt Code: | P06340 |
NCBI GenInfo Identifier: | 122210 |
NCBI Gene ID: | 3111 |
NCBI Accession: | P06340.1 |
UniProt Secondary Accession: | P06340,Q58HU0, Q58HU1, Q5STC7, Q9TQC6, Q9TQC7, Q9TQC8 Q9TQC9, Q9TQD0, Q9TQD1, Q9TQD2, Q9TQD3, |
UniProt Related Accession: | P06340 |
Molecular Weight: | 27,599 Da |
NCBI Full Name: | HLA class II histocompatibility antigen, DO alpha chain |
NCBI Synonym Full Names: | major histocompatibility complex, class II, DO alpha |
NCBI Official Symbol: | HLA-DOA |
NCBI Official Synonym Symbols: | HLADZ; HLA-DNA; HLA-DZA |
NCBI Protein Information: | HLA class II histocompatibility antigen, DO alpha chain |
UniProt Protein Name: | HLA class II histocompatibility antigen, DO alpha chain |
UniProt Synonym Protein Names: | MHC DN-alpha; MHC DZ alpha; MHC class II antigen DOA |
Protein Family: | HLA class II histocompatibility antigen |
UniProt Gene Name: | HLA-DOA |
UniProt Entry Name: | DOA_HUMAN |