HLA-DMB Antibody (PACO07410)
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주문- SKU:
- PACO07410
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | HLA-DMB Antibody (PACO07410) |
Antibody SKU: | PACO07410 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:10000-1:20000, IHC-p:1:50-1:300 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide from human protein at AA range: 40-100 |
Form: | Liquid |
Storage Buffer: | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemical analysis of paraffin-embedded Human-tonsil, antibody was diluted at 1:100. | |
Immunohistochemical analysis of paraffin-embedded Human-colon, antibody was diluted at 1:100. | |
Immunohistochemical analysis of paraffin-embedded Human-tonsil, antibody was diluted at 1:100. |
Synonyms: | HLA class II histocompatibility antigen, DM β chain (MHC class II antigen DMB) (Really interesting new gene 7 protein) |
UniProt Protein Function: | HLA-DMB: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Belongs to the MHC class II family. |
UniProt Protein Details: | Protein type:Vesicle; Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: lysosomal membrane; late endosome membrane; integral to membrane; MHC class II protein complex Biological Process: peptide antigen assembly with MHC class II protein complex; antigen processing and presentation of exogenous peptide antigen via MHC class II; positive regulation of T cell proliferation; immune response; MHC class II protein complex assembly |
NCBI Summary: | HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] |
UniProt Code: | P28068 |
NCBI GenInfo Identifier: | 133160 |
NCBI Gene ID: | 3109 |
NCBI Accession: | P28068.1 |
UniProt Related Accession: | P28068 |
Molecular Weight: | |
NCBI Full Name: | HLA class II histocompatibility antigen, DM beta chain |
NCBI Synonym Full Names: | major histocompatibility complex, class II, DM beta |
NCBI Official Symbol: | HLA-DMB |
NCBI Official Synonym Symbols: | RING7; D6S221E |
NCBI Protein Information: | HLA class II histocompatibility antigen, DM beta chain |
UniProt Protein Name: | HLA class II histocompatibility antigen, DM beta chain |
UniProt Synonym Protein Names: | MHC class II antigen DMB; Really interesting new gene 7 protein |
Protein Family: | HLA class II histocompatibility antigen |
UniProt Gene Name: | HLA-DMB |
UniProt Entry Name: | DMB_HUMAN |
Antibodies |
Anti-HLA-DMB Antibody (CAB8384) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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